Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer disease
Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostig...
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| Veröffentlicht in: | The Lancet (British edition) 1990-06, Vol.335 (8704), p.1484-1487 |
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| container_issue | 8704 |
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| container_title | The Lancet (British edition) |
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| creator | Geaney, D.P. Soper, N. Shepstone, B.J. Cowen, P.J. |
| description | Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls. |
| doi_str_mv | 10.1016/0140-6736(90)93028-N |
| format | Article |
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Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/0140-6736(90)93028-N</identifier><identifier>PMID: 1972432</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Aged ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Analysis of Variance ; Biological and medical sciences ; Brain ; Cerebrovascular Circulation - drug effects ; Cerebrovascular Circulation - physiology ; Circulatory system ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Drug Evaluation ; Female ; Glycopyrrolate - administration & dosage ; Glycopyrrolate - pharmacology ; Humans ; Infusions, Intravenous ; Male ; Medical research ; Medical sciences ; Middle Aged ; Neurology ; Organotechnetium Compounds ; Oximes ; Parasympathetic Nervous System - drug effects ; Parietal Lobe - blood supply ; Physostigmine - administration & dosage ; Physostigmine - antagonists & inhibitors ; Physostigmine - pharmacology ; Technetium ; Technetium Tc 99m Exametazime ; Temporal Lobe - blood supply ; Tomography, Emission-Computed, Single-Photon - methods</subject><ispartof>The Lancet (British edition), 1990-06, Vol.335 (8704), p.1484-1487</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><rights>Copyright Lancet Ltd. 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Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.</description><subject>Aged</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer's disease</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Circulatory system</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Drug Evaluation</subject><subject>Female</subject><subject>Glycopyrrolate - administration & dosage</subject><subject>Glycopyrrolate - pharmacology</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Organotechnetium Compounds</subject><subject>Oximes</subject><subject>Parasympathetic Nervous System - drug effects</subject><subject>Parietal Lobe - blood supply</subject><subject>Physostigmine - administration & dosage</subject><subject>Physostigmine - antagonists & inhibitors</subject><subject>Physostigmine - pharmacology</subject><subject>Technetium</subject><subject>Technetium Tc 99m Exametazime</subject><subject>Temporal Lobe - blood supply</subject><subject>Tomography, Emission-Computed, Single-Photon - methods</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUuL1TAUgIMo43X0HygUQdFFNWlP02QjDMP4gGHcKLgy5HEykyFtxqRV9Nebei8qLoRAAuc7ry-EPGT0BaOMv6QMaMvHnj-T9LnsaSfai1tkx2CEdoDx022y-43cJfdKuaaUAqfDETlicuyg73bk85n3aJcm-cbivGQdG3uVYpgxXwbblCVMa9RLSHNTT8bL-toYzGg22MSUXONj-taEuTmJP64wTJgbFwrqgvfJHa9jwQeH-5h8fH324fRte_7-zbvTk_PWAoOlRSN6ylEKBwJc13sDYDjX0tR5gTnk2qIfraQDgBce3TAKA50R3olOmP6YPN3Xvcnpy4plUVMoFmPUM6a1qFGKHthAK_j4H_A6rbmuVBSTsvoSvK8Q7CGbUykZvbrJYdL5u2JUbe7VJlZtYpWk6pd7dVHTHh1qr2ZC9ydpL7vGnxziulgdfdazDeUvrKvbjVv7V3sOq7GvAbMqNuBs0YVc_0q5FP4_yE_i9qCR</recordid><startdate>19900623</startdate><enddate>19900623</enddate><creator>Geaney, D.P.</creator><creator>Soper, N.</creator><creator>Shepstone, B.J.</creator><creator>Cowen, P.J.</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19900623</creationdate><title>Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer disease</title><author>Geaney, D.P. ; Soper, N. ; Shepstone, B.J. ; Cowen, P.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-eb8306e98d484d23fb44b66a9b46041de6acef7c90544f8fed578b42b8fd828b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Aged</topic><topic>Alzheimer Disease - diagnostic imaging</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer's disease</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Circulatory system</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. 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| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1990-06, Vol.335 (8704), p.1484-1487 |
| issn | 0140-6736 1474-547X |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Alzheimer Disease - diagnostic imaging Alzheimer Disease - physiopathology Alzheimer's disease Analysis of Variance Biological and medical sciences Brain Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Circulatory system Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Drug Evaluation Female Glycopyrrolate - administration & dosage Glycopyrrolate - pharmacology Humans Infusions, Intravenous Male Medical research Medical sciences Middle Aged Neurology Organotechnetium Compounds Oximes Parasympathetic Nervous System - drug effects Parietal Lobe - blood supply Physostigmine - administration & dosage Physostigmine - antagonists & inhibitors Physostigmine - pharmacology Technetium Technetium Tc 99m Exametazime Temporal Lobe - blood supply Tomography, Emission-Computed, Single-Photon - methods |
| title | Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer disease |
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