Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer disease

Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostig...

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Veröffentlicht in:	The Lancet (British edition) 1990-06, Vol.335 (8704), p.1484-1487
Hauptverfasser:	Geaney, D.P., Soper, N., Shepstone, B.J., Cowen, P.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - diagnostic imaging Alzheimer Disease - physiopathology Alzheimer's disease Analysis of Variance Biological and medical sciences Brain Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Circulatory system Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Drug Evaluation Female Glycopyrrolate - administration & dosage Glycopyrrolate - pharmacology Humans Infusions, Intravenous Male Medical research Medical sciences Middle Aged Neurology Organotechnetium Compounds Oximes Parasympathetic Nervous System - drug effects Parietal Lobe - blood supply Physostigmine - administration & dosage Physostigmine - antagonists & inhibitors Physostigmine - pharmacology Technetium Technetium Tc 99m Exametazime Temporal Lobe - blood supply Tomography, Emission-Computed, Single-Photon - methods
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Zusammenfassung:	Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.
ISSN:	0140-6736 1474-547X
DOI:	10.1016/0140-6736(90)93028-N