Yeast Ku as a regulator of chromosomal DNA end structure

During telomere replication in yeast, chromosome ends acquire an S-phase--specific overhang of the guanosine-rich strand. Here it is shown that in cells lacking Ku, a heterodimeric protein involved in nonhomologous DNA end joining, these overhangs are present throughout the cell cycle. In vivo cross...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1998-05, Vol.280 (5364), p.741-744
Hauptverfasser:	Gravel, S, Larrivee, M, Labrecque, P, Wellinger, R.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Nuclear Binding Sites Biological and medical sciences CELL CYCLE Cellular biology CHROMOSOME Chromosome replication CHROMOSOMES Chromosomes, Fungal - chemistry Chromosomes, Fungal - metabolism Classical genetics, quantitative genetics, hybrids CROMOSOMAS Deoxyribonucleic acid Diploidy DNA DNA Helicases DNA, Fungal - chemistry DNA, Fungal - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Fungal Proteins - metabolism G2 Phase Gels GENE GENES Genes, Fungal Genetic mutation GENETIC REGULATION GENETICA GENETICS Genetics of eukaryotes. Biological and molecular evolution GENETIQUE Ku Autoantigen Mitosis Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism Phenotypes Plasmids Proteins S Phase SACCHAROMYCES CEREVISIAE Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins Telomerase - genetics Telomerase - metabolism Telomere - metabolism TELOMERES Temperature Thallophyta, bryophyta Transformation, Genetic Vegetals Yeast Yeasts
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