influence of the milieu on the rate of neutralisation of herpes simplex virus 1

The rate of neutralisation of herpes simplex virus 1 was increased by up to more than five hundred-fold when the virus suspension and antiserum were each diluted to one hundred-fold in water instead of phosphate buffered saline. This phenomenon, which was observed for two human positive sera and a r...

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Veröffentlicht in:	Archives of virology 1998-01, Vol.143 (3), p.549-556
Hauptverfasser:	Bolt, C. E, Davies, J. A, Randall, S, Skinner, G. R. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - immunology Antigens, Viral - immunology antiserum Biological and medical sciences Fundamental and applied biological sciences. Psychology Herpes viruses Herpesvirus 1, Human - immunology Human herpesvirus 1 Humans inflammation Microbiology Miscellaneous neutralization Neutralization Tests neutralizing antibodies Proteins Rabbits Virology viruses
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Beschreibung
Zusammenfassung:	The rate of neutralisation of herpes simplex virus 1 was increased by up to more than five hundred-fold when the virus suspension and antiserum were each diluted to one hundred-fold in water instead of phosphate buffered saline. This phenomenon, which was observed for two human positive sera and a rabbit purified polyclonal antibody, may represent an unrecognised homeostatic mechanism where neutralising antibody is ‘dilution-fast’ under physiological conditions of transudation or pathological conditions of inflammation.
ISSN:	0304-8608 1432-8798
DOI:	10.1007/s007050050310