Synthesis and vasorelaxant activity of 2-fluoromethylbenzopyran potassium channel openers

The synthesis and vasorelaxant activity of 2-fluoromethylbenzopyran potassium channel openers are described. These (2-fluoromethyl) derivatives displayed smooth muscle relaxant activities comparable to or more potent than the corresponding 2-methyl analogues.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 1998-03, Vol.6 (3), p.323-337
Hauptverfasser:	Takahashi, Tadakatsu, Koga, Hiroshi, Sato, Haruhiko, Ishizawa, Takenori, Taka, Naoki, Imagawa, Jun-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - drug effects Benzopyrans - chemical synthesis Benzopyrans - pharmacology Hydrocarbons, Fluorinated - chemical synthesis Hydrocarbons, Fluorinated - pharmacology In Vitro Techniques Male Muscle, Smooth, Vascular - drug effects Potassium Channels - drug effects Rats Rats, Sprague-Dawley Structure-Activity Relationship Vasodilator Agents - chemical synthesis Vasodilator Agents - pharmacology
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Beschreibung
Zusammenfassung:	The synthesis and vasorelaxant activity of 2-fluoromethylbenzopyran potassium channel openers are described. These (2-fluoromethyl) derivatives displayed smooth muscle relaxant activities comparable to or more potent than the corresponding 2-methyl analogues.
ISSN:	0968-0896 1464-3391
DOI:	10.1016/S0968-0896(97)10035-9