Sonodynamically-induced cell damage with fluorinated anthracycline derivative, FAD104

Sonodynamically-induced cell damage with fluorinated anthracycline derivative, FAD104

The ultrasonically-induced in vitro cell damaging effect of fluorine-containing anthracycline derivative (FAD104) was investigated. Sarcoma 180 cells suspended in air-saturated PBS were exposed to ultrasound for up to 60 s in the presence and absence of FAD104. The rate of inducing cell damage with...

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Veröffentlicht in:Cancer letters 1998-03, Vol.125 (1), p.209-214
Hauptverfasser: Yumita, Nagahiko, Umemura, Shin-ichiro, Kaneuchi, Masahiro, Okano, Yukihiro, Magario, Naoki, Ishizaki, Midori, Shimizu, Keiko, Sano, Yasuko, Umemura, Koshiro, Nishigaki, Ryuichiro
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anthracycline derivative
Antibiotics, Antineoplastic - pharmacology
Biological and medical sciences
Cell damage
Doxorubicin - analogs & derivatives
Doxorubicin - pharmacology
Histidine - pharmacology
Male
Medical sciences
Mice
Mice, Inbred ICR
Other treatments
Sarcoma 180
Sarcoma 180 - drug therapy
Sarcoma 180 - pathology
Sonochemical mechanism
Treatment. General aspects
Tumors
Ultrasonics
Ultrasound
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Zusammenfassung:The ultrasonically-induced in vitro cell damaging effect of fluorine-containing anthracycline derivative (FAD104) was investigated. Sarcoma 180 cells suspended in air-saturated PBS were exposed to ultrasound for up to 60 s in the presence and absence of FAD104. The rate of inducing cell damage with ultrasound was doubled with 80 μM FAD104, while no cell damage was observed with FAD104 alone. This enhancement was significantly inhibited by histidine, which may suggest a sonochemical mechanism.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(97)00515-6