Evaluation of a microbiological method for zidovudine blood level determination
Zidovudine, a reverse transcriptase inhibitor, is used in the treatment of HIV and AIDS. We evaluated a microbiological method of determining serum levels of zidovudine. Serum levels of zidovudine were assayed by a microbiological method which used Escherichia coli (Kp 1976-712) as the test strain i...
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| Veröffentlicht in: | AIDS (London) 1990-03, Vol.4 (3), p.265-265 |
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| container_title | AIDS (London) |
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| creator | Etesse-Carsenti, H Carles, M Diquet, B Garraffo, R Mondain, V Bernard, E Dellamonica, P |
| description | Zidovudine, a reverse transcriptase inhibitor, is used in the treatment of HIV and AIDS. We evaluated a microbiological method of determining serum levels of zidovudine. Serum levels of zidovudine were assayed by a microbiological method which used Escherichia coli (Kp 1976-712) as the test strain in BAM 2 medium. The method was sensitive at a concentration of 25 ng/ml, which is similar to results obtained with high-pressure liquid chromatography (HPLC). This microbiological method has the advantage of being accessible to non-specialized laboratories and, in spite of its low cost, its accuracy is good. |
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| ispartof | AIDS (London), 1990-03, Vol.4 (3), p.265-265 |
| issn | 0269-9370 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | AIDS/HIV Bacteriological Techniques Biological Assay - methods Chromatography, High Pressure Liquid Escherichia coli Evaluation Studies as Topic human immunodeficiency virus Humans Zidovudine - blood |
| title | Evaluation of a microbiological method for zidovudine blood level determination |
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