Evidence that NMDA receptors contribute to synaptic function in the guinea pig medial vestibular nucleus

Single medial vestibular nucleus neurons were recorded from guinea pig brainstem slices in vitro while superfusing with the selective N- methyl- d-aspartate (NMDA) antagonists, MK801 and CPP. The majority of neurons tested showed a decrease in firing rate in response to these NMDA antagonists, sugge...

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Veröffentlicht in:	Brain research 1990-04, Vol.513 (1), p.149-151
Hauptverfasser:	Smith, Paul F., Darlington, Cynthia L., Hubbard, John I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Dibenzocycloheptenes - pharmacology Dizocilpine Maleate formula omitted Fundamental and applied biological sciences. Psychology Guinea Pigs Piperazines - pharmacology Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter - antagonists & inhibitors Receptors, Neurotransmitter - physiology Space life sciences Vertebrates: nervous system and sense organs Vestibular Nuclei - metabolism Vestibular Nuclei - physiology Vestibular nucleus
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Zusammenfassung:	Single medial vestibular nucleus neurons were recorded from guinea pig brainstem slices in vitro while superfusing with the selective N- methyl- d-aspartate (NMDA) antagonists, MK801 and CPP. The majority of neurons tested showed a decrease in firing rate in response to these NMDA antagonists, suggesting that NMDA receptors may contribute to the resting activity of MVN neurons.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(90)91101-L