677C to T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and plasma homocyst(e)ine levels in patients with TIA or minor stroke
It was the aim of this study to determine the associations of clinical and laboratory data with plasma homocyst(e)ine levels in patients with transient ischemic attack (TIA) or minor stroke (MS), with special reference to their 677C to T mutation status in the 5,10-methylenetetrahydrofolate reductas...
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| Veröffentlicht in: | Journal of the neurological sciences 1998-03, Vol.155 (2), p.156-162 |
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| creator | Lalouschek, Wolfgang Aull, Susanne Korninger, Lisa Mannhalter, Christine Pabinger-Fasching, Ingrid Schmid, Rainer W Peter Schnider Zeiler, Karl |
| description | It was the aim of this study to determine the associations of clinical and laboratory data with plasma homocyst(e)ine levels in patients with transient ischemic attack (TIA) or minor stroke (MS), with special reference to their 677C to T mutation status in the 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) gene. Seventy-six patients with TIA or MS were investigated at least 3
months after their (last) clinical event. By means of univariate analysis, significant correlations of homocyst(e)ine levels with male gender (
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| doi_str_mv | 10.1016/S0022-510X(97)00311-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79813192</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022510X97003110</els_id><sourcerecordid>79813192</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-509eb266cae905a7f87eb2a25d74f06e1de965fe684c6675a0538e5a070b117b3</originalsourceid><addsrcrecordid>eNqFkV2LEzEUhgdR1rr6ExZyIdKCoyeZzdeVLMV1F1YEreBdSDNnbHRm0k0yK_0h_l_TbemtNzmE9zkfvG9VXVB4R4GK998AGKs5hR9zLRcADaU1PKlmVElVc6Wap9XshDyvXqT0CwCEUvqsOtNcMCZgVv0VUi5JDmRFhinb7MNI_EjyBgl_S6EeMG92PY6YMUe72bUxdKG3GUnEdnLZJiTzz6ub668L8rNgxI4t2fY2DZZswhDcLuU5LnxRenzAPu2nb8seHHMif3zekNXtFQmRDH4sb8ox_MaX1bPO9glfHet59f3642p5U999-XS7vLqrXaN0rjloXDMhnEUN3MpOyfK3jLfysgOBtEUteIdCXTohJLfAG4WlSFhTKtfNefXmMHcbw_2EKZvBJ4d9b0cMUzJSK9pQzQrID6CLIaWIndlGP9i4MxTMPg7zGIfZe220NI9xGCh9F8cF03rA9tR19L_or4-6Tc72XbSj8-mEMaopY03BPhywYiA-eIwmueKgw9ZHdNm0wf_nkH9aF6bl</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79813192</pqid></control><display><type>article</type><title>677C to T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and plasma homocyst(e)ine levels in patients with TIA or minor stroke</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Lalouschek, Wolfgang ; Aull, Susanne ; Korninger, Lisa ; Mannhalter, Christine ; Pabinger-Fasching, Ingrid ; Schmid, Rainer W ; Peter Schnider ; Zeiler, Karl</creator><creatorcontrib>Lalouschek, Wolfgang ; Aull, Susanne ; Korninger, Lisa ; Mannhalter, Christine ; Pabinger-Fasching, Ingrid ; Schmid, Rainer W ; Peter Schnider ; Zeiler, Karl</creatorcontrib><description><![CDATA[It was the aim of this study to determine the associations of clinical and laboratory data with plasma homocyst(e)ine levels in patients with transient ischemic attack (TIA) or minor stroke (MS), with special reference to their 677C to T mutation status in the 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) gene. Seventy-six patients with TIA or MS were investigated at least 3
months after their (last) clinical event. By means of univariate analysis, significant correlations of homocyst(e)ine levels with male gender (
P<0.02), age (
P<0.0005), creatinine levels (
P<0.0002), folate levels (inversely,
P<0.05), and alcohol use (
P<0.02) were found, but not with vitamin B
12 levels. Multivariate regression analysis, including age, creatinine levels, and folate levels as independent variables, revealed age (
P<0.01) and creatinine levels (
P<0.02) to be significantly correlated with homocyst(e)ine levels. After adjustment for age, creatinine levels and homocyst(e)ine levels remained significantly correlated to each other (
P<0.005), whereas the relation between folate levels and homocyst(e)ine levels was no longer significant (
P=0.10). Mutation-positive patients exhibited moderately and statistically non-significantly higher homocyst(e)ine levels than mutation-negative patients, particularly those who were homozygous positive. Homocyst(e)ine levels were closely correlated with creatinine levels (
P<0.0002) and with folate levels (inversely,
P<0.05), but only in mutation-positive and not in mutation-negative patients. Homozygous positive, heterozygous positive, and mutation-negative patients did not differ with respect to clinical and laboratory data concerning ‘risk factors for stroke’ or co-existing vascular disease. In conclusion, the associations of creatinine levels and, inversely, of folate levels with plasma homocyst(e)ine levels in patients with TIA or MS are dependent on the 5,10-MTHFR mutation status. Significant correlations between these variables were found only in mutation-positive but not in mutation-negative patients.]]></description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/S0022-510X(97)00311-0</identifier><identifier>PMID: 9562260</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>5,10-Methylenetetrahydrofolate Reductase (FADH2) ; Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Biological and medical sciences ; Cerebrovascular diseases ; Cerebrovascular Disorders - blood ; Cerebrovascular Disorders - enzymology ; Cerebrovascular Disorders - genetics ; Creatinine ; Female ; Folate ; Folic Acid - blood ; Genetic disorders ; Homocyst(e)ine ; Homocysteine - blood ; Humans ; Ischemic Attack, Transient - blood ; Ischemic Attack, Transient - enzymology ; Ischemic Attack, Transient - genetics ; Male ; Medical sciences ; Methylenetetrahydrofolate Reductase (NADPH2) ; Middle Aged ; MTHFR ; Mutation - physiology ; Neurology ; Oxidoreductases - genetics ; Risk Factors ; Vascular diseases and vascular malformations of the nervous system ; Vitamin B 12 - blood</subject><ispartof>Journal of the neurological sciences, 1998-03, Vol.155 (2), p.156-162</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-509eb266cae905a7f87eb2a25d74f06e1de965fe684c6675a0538e5a070b117b3</citedby><cites>FETCH-LOGICAL-c389t-509eb266cae905a7f87eb2a25d74f06e1de965fe684c6675a0538e5a070b117b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-510X(97)00311-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2191223$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9562260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lalouschek, Wolfgang</creatorcontrib><creatorcontrib>Aull, Susanne</creatorcontrib><creatorcontrib>Korninger, Lisa</creatorcontrib><creatorcontrib>Mannhalter, Christine</creatorcontrib><creatorcontrib>Pabinger-Fasching, Ingrid</creatorcontrib><creatorcontrib>Schmid, Rainer W</creatorcontrib><creatorcontrib>Peter Schnider</creatorcontrib><creatorcontrib>Zeiler, Karl</creatorcontrib><title>677C to T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and plasma homocyst(e)ine levels in patients with TIA or minor stroke</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description><![CDATA[It was the aim of this study to determine the associations of clinical and laboratory data with plasma homocyst(e)ine levels in patients with transient ischemic attack (TIA) or minor stroke (MS), with special reference to their 677C to T mutation status in the 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) gene. Seventy-six patients with TIA or MS were investigated at least 3
months after their (last) clinical event. By means of univariate analysis, significant correlations of homocyst(e)ine levels with male gender (
P<0.02), age (
P<0.0005), creatinine levels (
P<0.0002), folate levels (inversely,
P<0.05), and alcohol use (
P<0.02) were found, but not with vitamin B
12 levels. Multivariate regression analysis, including age, creatinine levels, and folate levels as independent variables, revealed age (
P<0.01) and creatinine levels (
P<0.02) to be significantly correlated with homocyst(e)ine levels. After adjustment for age, creatinine levels and homocyst(e)ine levels remained significantly correlated to each other (
P<0.005), whereas the relation between folate levels and homocyst(e)ine levels was no longer significant (
P=0.10). Mutation-positive patients exhibited moderately and statistically non-significantly higher homocyst(e)ine levels than mutation-negative patients, particularly those who were homozygous positive. Homocyst(e)ine levels were closely correlated with creatinine levels (
P<0.0002) and with folate levels (inversely,
P<0.05), but only in mutation-positive and not in mutation-negative patients. Homozygous positive, heterozygous positive, and mutation-negative patients did not differ with respect to clinical and laboratory data concerning ‘risk factors for stroke’ or co-existing vascular disease. In conclusion, the associations of creatinine levels and, inversely, of folate levels with plasma homocyst(e)ine levels in patients with TIA or MS are dependent on the 5,10-MTHFR mutation status. Significant correlations between these variables were found only in mutation-positive but not in mutation-negative patients.]]></description><subject>5,10-Methylenetetrahydrofolate Reductase (FADH2)</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Cerebrovascular diseases</subject><subject>Cerebrovascular Disorders - blood</subject><subject>Cerebrovascular Disorders - enzymology</subject><subject>Cerebrovascular Disorders - genetics</subject><subject>Creatinine</subject><subject>Female</subject><subject>Folate</subject><subject>Folic Acid - blood</subject><subject>Genetic disorders</subject><subject>Homocyst(e)ine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Ischemic Attack, Transient - blood</subject><subject>Ischemic Attack, Transient - enzymology</subject><subject>Ischemic Attack, Transient - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2)</subject><subject>Middle Aged</subject><subject>MTHFR</subject><subject>Mutation - physiology</subject><subject>Neurology</subject><subject>Oxidoreductases - genetics</subject><subject>Risk Factors</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Vitamin B 12 - blood</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV2LEzEUhgdR1rr6ExZyIdKCoyeZzdeVLMV1F1YEreBdSDNnbHRm0k0yK_0h_l_TbemtNzmE9zkfvG9VXVB4R4GK998AGKs5hR9zLRcADaU1PKlmVElVc6Wap9XshDyvXqT0CwCEUvqsOtNcMCZgVv0VUi5JDmRFhinb7MNI_EjyBgl_S6EeMG92PY6YMUe72bUxdKG3GUnEdnLZJiTzz6ub668L8rNgxI4t2fY2DZZswhDcLuU5LnxRenzAPu2nb8seHHMif3zekNXtFQmRDH4sb8ox_MaX1bPO9glfHet59f3642p5U999-XS7vLqrXaN0rjloXDMhnEUN3MpOyfK3jLfysgOBtEUteIdCXTohJLfAG4WlSFhTKtfNefXmMHcbw_2EKZvBJ4d9b0cMUzJSK9pQzQrID6CLIaWIndlGP9i4MxTMPg7zGIfZe220NI9xGCh9F8cF03rA9tR19L_or4-6Tc72XbSj8-mEMaopY03BPhywYiA-eIwmueKgw9ZHdNm0wf_nkH9aF6bl</recordid><startdate>19980305</startdate><enddate>19980305</enddate><creator>Lalouschek, Wolfgang</creator><creator>Aull, Susanne</creator><creator>Korninger, Lisa</creator><creator>Mannhalter, Christine</creator><creator>Pabinger-Fasching, Ingrid</creator><creator>Schmid, Rainer W</creator><creator>Peter Schnider</creator><creator>Zeiler, Karl</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980305</creationdate><title>677C to T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and plasma homocyst(e)ine levels in patients with TIA or minor stroke</title><author>Lalouschek, Wolfgang ; Aull, Susanne ; Korninger, Lisa ; Mannhalter, Christine ; Pabinger-Fasching, Ingrid ; Schmid, Rainer W ; Peter Schnider ; Zeiler, Karl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-509eb266cae905a7f87eb2a25d74f06e1de965fe684c6675a0538e5a070b117b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>5,10-Methylenetetrahydrofolate Reductase (FADH2)</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Cerebrovascular diseases</topic><topic>Cerebrovascular Disorders - blood</topic><topic>Cerebrovascular Disorders - enzymology</topic><topic>Cerebrovascular Disorders - genetics</topic><topic>Creatinine</topic><topic>Female</topic><topic>Folate</topic><topic>Folic Acid - blood</topic><topic>Genetic disorders</topic><topic>Homocyst(e)ine</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Ischemic Attack, Transient - blood</topic><topic>Ischemic Attack, Transient - enzymology</topic><topic>Ischemic Attack, Transient - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2)</topic><topic>Middle Aged</topic><topic>MTHFR</topic><topic>Mutation - physiology</topic><topic>Neurology</topic><topic>Oxidoreductases - genetics</topic><topic>Risk Factors</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Vitamin B 12 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lalouschek, Wolfgang</creatorcontrib><creatorcontrib>Aull, Susanne</creatorcontrib><creatorcontrib>Korninger, Lisa</creatorcontrib><creatorcontrib>Mannhalter, Christine</creatorcontrib><creatorcontrib>Pabinger-Fasching, Ingrid</creatorcontrib><creatorcontrib>Schmid, Rainer W</creatorcontrib><creatorcontrib>Peter Schnider</creatorcontrib><creatorcontrib>Zeiler, Karl</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lalouschek, Wolfgang</au><au>Aull, Susanne</au><au>Korninger, Lisa</au><au>Mannhalter, Christine</au><au>Pabinger-Fasching, Ingrid</au><au>Schmid, Rainer W</au><au>Peter Schnider</au><au>Zeiler, Karl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>677C to T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and plasma homocyst(e)ine levels in patients with TIA or minor stroke</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1998-03-05</date><risdate>1998</risdate><volume>155</volume><issue>2</issue><spage>156</spage><epage>162</epage><pages>156-162</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract><![CDATA[It was the aim of this study to determine the associations of clinical and laboratory data with plasma homocyst(e)ine levels in patients with transient ischemic attack (TIA) or minor stroke (MS), with special reference to their 677C to T mutation status in the 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) gene. Seventy-six patients with TIA or MS were investigated at least 3
months after their (last) clinical event. By means of univariate analysis, significant correlations of homocyst(e)ine levels with male gender (
P<0.02), age (
P<0.0005), creatinine levels (
P<0.0002), folate levels (inversely,
P<0.05), and alcohol use (
P<0.02) were found, but not with vitamin B
12 levels. Multivariate regression analysis, including age, creatinine levels, and folate levels as independent variables, revealed age (
P<0.01) and creatinine levels (
P<0.02) to be significantly correlated with homocyst(e)ine levels. After adjustment for age, creatinine levels and homocyst(e)ine levels remained significantly correlated to each other (
P<0.005), whereas the relation between folate levels and homocyst(e)ine levels was no longer significant (
P=0.10). Mutation-positive patients exhibited moderately and statistically non-significantly higher homocyst(e)ine levels than mutation-negative patients, particularly those who were homozygous positive. Homocyst(e)ine levels were closely correlated with creatinine levels (
P<0.0002) and with folate levels (inversely,
P<0.05), but only in mutation-positive and not in mutation-negative patients. Homozygous positive, heterozygous positive, and mutation-negative patients did not differ with respect to clinical and laboratory data concerning ‘risk factors for stroke’ or co-existing vascular disease. In conclusion, the associations of creatinine levels and, inversely, of folate levels with plasma homocyst(e)ine levels in patients with TIA or MS are dependent on the 5,10-MTHFR mutation status. Significant correlations between these variables were found only in mutation-positive but not in mutation-negative patients.]]></abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>9562260</pmid><doi>10.1016/S0022-510X(97)00311-0</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-510X |
| ispartof | Journal of the neurological sciences, 1998-03, Vol.155 (2), p.156-162 |
| issn | 0022-510X 1878-5883 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79813192 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 5,10-Methylenetetrahydrofolate Reductase (FADH2) Adult Aged Aged, 80 and over Analysis of Variance Biological and medical sciences Cerebrovascular diseases Cerebrovascular Disorders - blood Cerebrovascular Disorders - enzymology Cerebrovascular Disorders - genetics Creatinine Female Folate Folic Acid - blood Genetic disorders Homocyst(e)ine Homocysteine - blood Humans Ischemic Attack, Transient - blood Ischemic Attack, Transient - enzymology Ischemic Attack, Transient - genetics Male Medical sciences Methylenetetrahydrofolate Reductase (NADPH2) Middle Aged MTHFR Mutation - physiology Neurology Oxidoreductases - genetics Risk Factors Vascular diseases and vascular malformations of the nervous system Vitamin B 12 - blood |
| title | 677C to T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and plasma homocyst(e)ine levels in patients with TIA or minor stroke |
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