677C to T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and plasma homocyst(e)ine levels in patients with TIA or minor stroke

677C to T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and plasma homocyst(e)ine levels in patients with TIA or minor stroke

It was the aim of this study to determine the associations of clinical and laboratory data with plasma homocyst(e)ine levels in patients with transient ischemic attack (TIA) or minor stroke (MS), with special reference to their 677C to T mutation status in the 5,10-methylenetetrahydrofolate reductas...

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Veröffentlicht in:Journal of the neurological sciences 1998-03, Vol.155 (2), p.156-162
Hauptverfasser: Lalouschek, Wolfgang, Aull, Susanne, Korninger, Lisa, Mannhalter, Christine, Pabinger-Fasching, Ingrid, Schmid, Rainer W, Peter Schnider, Zeiler, Karl
Format: Artikel
Sprache:eng
Schlagworte:
5,10-Methylenetetrahydrofolate Reductase (FADH2)
Adult
Aged
Aged, 80 and over
Analysis of Variance
Biological and medical sciences
Cerebrovascular diseases
Cerebrovascular Disorders - blood
Cerebrovascular Disorders - enzymology
Cerebrovascular Disorders - genetics
Creatinine
Female
Folate
Folic Acid - blood
Genetic disorders
Homocyst(e)ine
Homocysteine - blood
Humans
Ischemic Attack, Transient - blood
Ischemic Attack, Transient - enzymology
Ischemic Attack, Transient - genetics
Male
Medical sciences
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
MTHFR
Mutation - physiology
Neurology
Oxidoreductases - genetics
Risk Factors
Vascular diseases and vascular malformations of the nervous system
Vitamin B 12 - blood
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Zusammenfassung:It was the aim of this study to determine the associations of clinical and laboratory data with plasma homocyst(e)ine levels in patients with transient ischemic attack (TIA) or minor stroke (MS), with special reference to their 677C to T mutation status in the 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) gene. Seventy-six patients with TIA or MS were investigated at least 3 months after their (last) clinical event. By means of univariate analysis, significant correlations of homocyst(e)ine levels with male gender ( P
ISSN:0022-510X
1878-5883
DOI:10.1016/S0022-510X(97)00311-0