Pharmacokinetics and Protein Binding of Eprosartan in Healthy Volunteers and in Patients with Varying Degrees of Renal Impairment

This was an open‐label, parallel group study to compare the pharmacokinetics of multiple oral doses of eprosartan in subjects with normal renal function (Clcr >80 mL/min; n = 8) and patients with mild (Clcr 60–80 mL/min; n = 8), moderate (Clcr 30–59 mL/min; n = 15), or severe (Clcr

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of clinical pharmacology 1998-02, Vol.38 (2), p.129-137
Hauptverfasser:	Martin, David E., Chapelsky, Martha C., Ilson, Bernard, Tenero, David, Boike, Steven C., Zariffa, Névine, Jorkasky, Diane K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates - administration & dosage Acrylates - blood Acrylates - pharmacokinetics Adult Aged Antihypertensive agents Antihypertensive Agents - administration & dosage Antihypertensive Agents - blood Antihypertensive Agents - pharmacokinetics Area Under Curve Biological and medical sciences Cardiovascular system Humans Imidazoles - administration & dosage Imidazoles - blood Imidazoles - pharmacokinetics Medical sciences Metabolic Clearance Rate Middle Aged Pharmacology. Drug treatments Renal Insufficiency - blood Renal Insufficiency - metabolism Thiophenes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	This was an open‐label, parallel group study to compare the pharmacokinetics of multiple oral doses of eprosartan in subjects with normal renal function (Clcr >80 mL/min; n = 8) and patients with mild (Clcr 60–80 mL/min; n = 8), moderate (Clcr 30–59 mL/min; n = 15), or severe (Clcr
ISSN:	0091-2700 1552-4604
DOI:	10.1002/j.1552-4604.1998.tb04401.x