A new platelet function test

A method for screening EDTA (K 3) blood samples for platelet function is described. The general availability of whole blood platelet counters in the clinical laboratory suggested their use to measure platelet aggregation. To simplify the collection and storage of blood samples, a method utilizing ED...

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Veröffentlicht in:	Thrombosis research 1990-04, Vol.58 (2), p.163-173
Hauptverfasser:	Ryan, Wayne L., Hakenkamp, Kay, Sullivan, Erin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Aggregation Arachidonic Acid Arachidonic Acids - pharmacology Aspirin - pharmacology Biological and medical sciences Bleeding Time Blood coagulation. Blood cells Blood Specimen Collection - methods Calcium - pharmacology Collagen - pharmacology Edetic Acid Fundamental and applied biological sciences. Psychology Humans Molecular and cellular biology Platelet Platelet Aggregation - drug effects Platelet Count Platelet Function Tests - methods Ristocetin - pharmacology Test
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Beschreibung
Zusammenfassung:	A method for screening EDTA (K 3) blood samples for platelet function is described. The general availability of whole blood platelet counters in the clinical laboratory suggested their use to measure platelet aggregation. To simplify the collection and storage of blood samples, a method utilizing EDTA collected blood is described. Addition of calcium and citrate restores platelet function to blood samples even when stored at room temperature for several hours. Thus, the blood sample used to assay RBC, WBC and platelet parameters may also be employed in platelet aggregation. A comparison of this method with aggregometry on 120 subjects indicated a similar response to arachidonate, collagen, ristocetin and ADP.
ISSN:	0049-3848 1879-2472
DOI:	10.1016/0049-3848(90)90173-A