Relationship between lucigenin-enhanced chemiluminescence and uroporphyrinogen oxidation in mouse and chick embryo liver microsomes

Three approaches have been used to detect reactive oxygen species production in such cytochrome P450-mediated reactions: lipid peroxidation, chemiluminescence and uroporphyrinogen oxidation. We have now used liver microsomes from chick embryos and mice treated with known inducers of cytochrome P450...

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Veröffentlicht in:	Biochemical pharmacology 1990-06, Vol.39 (11), p.1828-1830
Hauptverfasser:	Sinclair, Peter R., Jacobs, Judith M., Deam, Susan M., Lambrecht, Richard W., Sinclair, Jacqueline F., Elder, George H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - pharmacology Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases chemiluminescence Chick Embryo Cytochrome P-450 Enzyme System - metabolism lucigenin Luminescent Measurements Male Medical sciences Mice Mice, Inbred AKR Mice, Inbred C57BL Mice, Inbred DBA microsomes Microsomes, Liver - metabolism Oxidation-Reduction Porphyrinogens - metabolism Toxicology uroporphyrinogen Uroporphyrinogens - metabolism Various organic compounds
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