Plasma tryptophan to large neutral amino acid ratios in depressed and normal subjects

The ratios of total and free plasma tryptophan to the sum of five large neutral amino acids (LNAAs) were found to be significantly lower in a group of 16 depressed inpatients compared to nine normal subjects after oral loading with L-tryptophan. The group differences in these ratios were significant...

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Veröffentlicht in:	Journal of affective disorders 1990-05, Vol.19 (1), p.9-14
Hauptverfasser:	Russ, M J, Ackerman, S H, Banay-Schwartz, M, Shindledecker, R D, Smith, G P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Amino Acids - blood Blood-Brain Barrier - drug effects Depressive Disorder - blood Depressive Disorder - drug therapy Depressive Disorder - psychology Desipramine - administration & dosage Double-Blind Method Eating - drug effects Female Humans Imipramine - administration & dosage Male Middle Aged Nortriptyline - administration & dosage Psychiatric Status Rating Scales Randomized Controlled Trials as Topic Tryptophan - administration & dosage Tryptophan - blood
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Zusammenfassung:	The ratios of total and free plasma tryptophan to the sum of five large neutral amino acids (LNAAs) were found to be significantly lower in a group of 16 depressed inpatients compared to nine normal subjects after oral loading with L-tryptophan. The group differences in these ratios were significant before, and 2 weeks after starting treatment with a tricyclic antidepressant. Plasma tryptophan ratios and severity of depression were not significantly correlated.
ISSN:	0165-0327
DOI:	10.1016/0165-0327(90)90003-q