Capture of an early fusion-active conformation of HIV-1 gp41

Using an inhibitory synthetic peptide (DP-178) from HIV-1 gp41, we have trapped HIV-1 envelope glycoprotein (Env) undergoing conformational changes during virus entry. Our data show that DP-178 binds gp41 and inhibits Env-mediated membrane fusion after gp120 interacts with cellular receptors, indica...

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Veröffentlicht in:Nature Structural Biology 1998-04, Vol.5 (4), p.276-279
Hauptverfasser: Furuta, Rika A, Wild, Carl T, Weng, Yongkai, Weiss, Carol D
Format: Artikel
Sprache:eng
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Zusammenfassung:Using an inhibitory synthetic peptide (DP-178) from HIV-1 gp41, we have trapped HIV-1 envelope glycoprotein (Env) undergoing conformational changes during virus entry. Our data show that DP-178 binds gp41 and inhibits Env-mediated membrane fusion after gp120 interacts with cellular receptors, indicating that conformational changes involving the coiled coil domain of gp41 are required for entry. Capture of this fusion-active conformation of Env provides insights into the early events leading to Env-mediated membrane fusion.
ISSN:1072-8368
2331-365X
1545-9985
DOI:10.1038/nsb0498-276