Trending of impedance-monitored cardiac variables: Method and statistical power analysis of 100 control studies in a pediatric intensive care unit

The NCCOM3-R6 monitor continuously monitors cardiac output and five other cardiovascular variables from the thoracic electrical bioimpedance signal. We averaged data over 5-min intervals for 130 min in 100 control studies in 40 pediatric ICU patients, age 0.04 to 20.39 yr (median 1.39) and weighing 2.0 to 59.5 kg (median 8.8). For individual studies, 99% of the 5-min averages of cardiac output fell within ±44% of the baseline cardiac output for that study. Normal ranges were somewhat narrower for the other five variables. When we averaged data for 100 studies, 5-min interval observations for each variable did not deviate from baseline over a 2-h period (p >.70). With a sample size of 100 studies, we could detect a change in cardiac output of ±5% at the p