Interference With Immune Response at the Level of Generating Effector Cells by Tumor-Associated Haptoglobin
Most of the immune response regulators identified to date proved to be products of tumor, of an immune system or of combinations of such systems or to be tumor-induced host products. We have described how the haptoglobin isolated from cancer patients can impose serious hindrance to cell-mediated imm...
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Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1990-06, Vol.82 (11), p.934-940 |
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container_title | JNCI : Journal of the National Cancer Institute |
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creator | Oh, Se-Kyung Kim, Soon-Han Walker, John E. |
description | Most of the immune response regulators identified to date proved to be products of tumor, of an immune system or of combinations of such systems or to be tumor-induced host products. We have described how the haptoglobin isolated from cancer patients can impose serious hindrance to cell-mediated immune functions in vivo and in vitro under the pathophysiologic concentrations seen in these patients. Because the tumor-associated haptoglobin interferes with the innate and adaptive immune functions, elimination of the haptoglobin by passive removal or by active therapy could be an important adjunct for immunotherapy in cancer patients. [J Natl Cancer Inst 82:934–940, 1990] |
doi_str_mv | 10.1093/jnci/82.11.934 |
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We have described how the haptoglobin isolated from cancer patients can impose serious hindrance to cell-mediated immune functions in vivo and in vitro under the pathophysiologic concentrations seen in these patients. Because the tumor-associated haptoglobin interferes with the innate and adaptive immune functions, elimination of the haptoglobin by passive removal or by active therapy could be an important adjunct for immunotherapy in cancer patients. [J Natl Cancer Inst 82:934–940, 1990]</description><subject>Animals</subject><subject>Antibody Formation</subject><subject>Biological and medical sciences</subject><subject>Cytotoxicity, Immunologic</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Haptoglobins - pharmacology</subject><subject>Histocompatibility Antigens Class I - immunology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Isoantigens - metabolism</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - metabolism</subject><subject>T-Lymphocytes - immunology</subject><subject>Tumors</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v00AQxVcIVELhyg1pD4ib09kve_dYRaWJFAmJRlBxWa3t2dat7Q27a0T_exwlypW5zOH93mhmHiEfGSwZGHH1NDbdleZLxpZGyFdkwWQJBWegXpMFAK8KrSv5lrxL6QnmMlxekAvOJEgOC_K8GTNGjxHHBunPLj_SzTBMI9LvmPZhTEhdpvkR6Rb_YE-Dp7c4YnS5Gx_ojffY5BDpCvs-0fqF7qYhxOI6pdB0LmNL126fw0Mf6m58T9541yf8cOqXZPf1ZrdaF9tvt5vV9bZohNa5UF7oWgpgvJXOlQA1595D2YBAKGtZtsCU0VgaV6KUzigmlTKtdh5aQHFJvhzH7mP4PWHKduhSMy_oRgxTspWpKqMl-y_IVAWV4QdweQSbGFKK6O0-doOLL5aBPaRgDylYzS1jdk5hNnw6TZ7qAdszfnr7rH8-6S41rvfRzf50xmTJ1HzRjBVHrEsZ_55lF59tWYlK2fX9L3u3ulsLuP9hd-IfsdqfKA</recordid><startdate>19900606</startdate><enddate>19900606</enddate><creator>Oh, Se-Kyung</creator><creator>Kim, Soon-Han</creator><creator>Walker, John E.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19900606</creationdate><title>Interference With Immune Response at the Level of Generating Effector Cells by Tumor-Associated Haptoglobin</title><author>Oh, Se-Kyung ; Kim, Soon-Han ; Walker, John E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-5f38b43012d4aa600b22ff06c03e06b46d01598e69a6e44a9514559d8af0d0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Antibody Formation</topic><topic>Biological and medical sciences</topic><topic>Cytotoxicity, Immunologic</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Haptoglobins - pharmacology</topic><topic>Histocompatibility Antigens Class I - immunology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Isoantigens - metabolism</topic><topic>Killer Cells, Natural - immunology</topic><topic>Lymphocyte Culture Test, Mixed</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - metabolism</topic><topic>T-Lymphocytes - immunology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, Se-Kyung</creatorcontrib><creatorcontrib>Kim, Soon-Han</creatorcontrib><creatorcontrib>Walker, John E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh, Se-Kyung</au><au>Kim, Soon-Han</au><au>Walker, John E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interference With Immune Response at the Level of Generating Effector Cells by Tumor-Associated Haptoglobin</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>J Natl Cancer Inst</addtitle><date>1990-06-06</date><risdate>1990</risdate><volume>82</volume><issue>11</issue><spage>934</spage><epage>940</epage><pages>934-940</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>Most of the immune response regulators identified to date proved to be products of tumor, of an immune system or of combinations of such systems or to be tumor-induced host products. 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subjects | Animals Antibody Formation Biological and medical sciences Cytotoxicity, Immunologic Dose-Response Relationship, Drug Electrophoresis, Polyacrylamide Gel Haptoglobins - pharmacology Histocompatibility Antigens Class I - immunology Humans In Vitro Techniques Isoantigens - metabolism Killer Cells, Natural - immunology Lymphocyte Culture Test, Mixed Medical sciences Mice Mice, Inbred BALB C Neoplasms - immunology Neoplasms - metabolism T-Lymphocytes - immunology Tumors |
title | Interference With Immune Response at the Level of Generating Effector Cells by Tumor-Associated Haptoglobin |
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