Interference With Immune Response at the Level of Generating Effector Cells by Tumor-Associated Haptoglobin

Most of the immune response regulators identified to date proved to be products of tumor, of an immune system or of combinations of such systems or to be tumor-induced host products. We have described how the haptoglobin isolated from cancer patients can impose serious hindrance to cell-mediated imm...

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Veröffentlicht in:JNCI : Journal of the National Cancer Institute 1990-06, Vol.82 (11), p.934-940
Hauptverfasser: Oh, Se-Kyung, Kim, Soon-Han, Walker, John E.
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container_end_page 940
container_issue 11
container_start_page 934
container_title JNCI : Journal of the National Cancer Institute
container_volume 82
creator Oh, Se-Kyung
Kim, Soon-Han
Walker, John E.
description Most of the immune response regulators identified to date proved to be products of tumor, of an immune system or of combinations of such systems or to be tumor-induced host products. We have described how the haptoglobin isolated from cancer patients can impose serious hindrance to cell-mediated immune functions in vivo and in vitro under the pathophysiologic concentrations seen in these patients. Because the tumor-associated haptoglobin interferes with the innate and adaptive immune functions, elimination of the haptoglobin by passive removal or by active therapy could be an important adjunct for immunotherapy in cancer patients. [J Natl Cancer Inst 82:934–940, 1990]
doi_str_mv 10.1093/jnci/82.11.934
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subjects Animals
Antibody Formation
Biological and medical sciences
Cytotoxicity, Immunologic
Dose-Response Relationship, Drug
Electrophoresis, Polyacrylamide Gel
Haptoglobins - pharmacology
Histocompatibility Antigens Class I - immunology
Humans
In Vitro Techniques
Isoantigens - metabolism
Killer Cells, Natural - immunology
Lymphocyte Culture Test, Mixed
Medical sciences
Mice
Mice, Inbred BALB C
Neoplasms - immunology
Neoplasms - metabolism
T-Lymphocytes - immunology
Tumors
title Interference With Immune Response at the Level of Generating Effector Cells by Tumor-Associated Haptoglobin
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