Genetic Selection of Alcohol Preference Can Be Countered by Conditioning Processes

Twenty-four P rats and 24 NP rats were conditioned to consume 10% w/v alcohol in daily 0.5-h limited access periods using a modified version of Samson’s sucrose fading procedure. Both P and NP rats demonstrated a strikingly similar day-to-day pattern of alcohol intakes. For the most part, P rats dra...

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Veröffentlicht in:	Alcohol (Fayetteville, N.Y.) N.Y.), 1998-04, Vol.15 (3), p.199-206
Hauptverfasser:	Gauvin, David V, Vanecek, Susan A, Baird, Theodore J, Briscoe, Richard J, Vallett, Mary, Holloway, Frank A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Drinking - genetics Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Conditioning Conditioning (Psychology) Ethanol - administration & dosage Ethanol self-administration Food Preferences Genetic selection Home-cage drinking Limited access Male Medical sciences NP rats P rats Rats Rats, Sprague-Dawley Rats, Wistar Solutions Sucrose - administration & dosage Toxicology
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Beschreibung
Zusammenfassung:	Twenty-four P rats and 24 NP rats were conditioned to consume 10% w/v alcohol in daily 0.5-h limited access periods using a modified version of Samson’s sucrose fading procedure. Both P and NP rats demonstrated a strikingly similar day-to-day pattern of alcohol intakes. For the most part, P rats drank more than NP rats, but by the middle of the fourth month of drinking, P and NP rats were drinking equivalent amounts of alcohol. Both P and NP rats consumed alcohol in amounts similar to two outbred strains of rats (Wistar and Sprague–Dawley) previously conditioned to drink alcohol in this laboratory.
ISSN:	0741-8329 1873-6823
DOI:	10.1016/S0741-8329(97)00112-2