V region sequences of an idiotypically connected family of pathogenic anti-DNA autoantibodies
The H and L chain V region sequences of nine anti-DNA mAb that are representative of a pathogenic population of autoantibodies produced by the nephritis prone (SWR x NZB)F1 (SNF1) mice, were determined. These nine anti-DNA autoantibodies were idiotypically connected members of a cross-reactive Id fa...
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Veröffentlicht in: | The Journal of immunology (1950) 1990-06, Vol.144 (11), p.4275-4283 |
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creator | O'Keefe, TL Bandyopadhyay, S Datta, SK Imanishi-Kari, T |
description | The H and L chain V region sequences of nine anti-DNA mAb that are representative of a pathogenic population of autoantibodies produced by the nephritis prone (SWR x NZB)F1 (SNF1) mice, were determined. These nine anti-DNA autoantibodies were idiotypically connected members of a cross-reactive Id family called the Id564 cluster. Moreover, these autoantibodies were all cationic in charge, IgG2b in isotype, and their H chain C regions had the normal SWR parent's allotype. Although derived from two different SNF1 animals, these pathogenic autoantibodies possessed highly homologous Leader-VH sequences that could account for their idiotypic cross-reactivity. Furthermore, the VH region sequences of these anti-DNA antibodies contained numerous basic residues that could impart their cationic charge. The Leader-VH sequences of these autoantibodies were also highly homologous to that of an anti-NP antibody-related germ-line gene of C57BL/6 mice, called VH-23. Among these nine pathogenic autoantibodies, three sets of clonally related anti-DNA antibodies could be identified. Thus the Id564 cluster of cationic anti-DNA autoantibodies of SNF1 mice are encoded by highly related VH genes, and this idiotypically connected population of pathogenic autoantibodies are selected to undergo an oligoclonal expansion in the lupus-prone SNF1 mice. |
doi_str_mv | 10.4049/jimmunol.144.11.4275 |
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These nine anti-DNA autoantibodies were idiotypically connected members of a cross-reactive Id family called the Id564 cluster. Moreover, these autoantibodies were all cationic in charge, IgG2b in isotype, and their H chain C regions had the normal SWR parent's allotype. Although derived from two different SNF1 animals, these pathogenic autoantibodies possessed highly homologous Leader-VH sequences that could account for their idiotypic cross-reactivity. Furthermore, the VH region sequences of these anti-DNA antibodies contained numerous basic residues that could impart their cationic charge. The Leader-VH sequences of these autoantibodies were also highly homologous to that of an anti-NP antibody-related germ-line gene of C57BL/6 mice, called VH-23. Among these nine pathogenic autoantibodies, three sets of clonally related anti-DNA antibodies could be identified. Thus the Id564 cluster of cationic anti-DNA autoantibodies of SNF1 mice are encoded by highly related VH genes, and this idiotypically connected population of pathogenic autoantibodies are selected to undergo an oligoclonal expansion in the lupus-prone SNF1 mice.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.144.11.4275</identifier><identifier>PMID: 2341721</identifier><identifier>CODEN: JOIMA3</identifier><language>eng</language><publisher>Bethesda, MD: Am Assoc Immnol</publisher><subject>Amino Acid Sequence ; Animals ; Antibodies, Antinuclear - genetics ; Base Sequence ; Biological and medical sciences ; Blotting, Southern ; Fundamental and applied biological sciences. Psychology ; Genes, Immunoglobulin ; Genes. Genome ; Immunoglobulin Constant Regions - genetics ; Immunoglobulin G - genetics ; Immunoglobulin Idiotypes - genetics ; Immunoglobulin Variable Region - genetics ; Isoelectric Point ; Mice ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Nephritis - genetics ; Nephritis - immunology</subject><ispartof>The Journal of immunology (1950), 1990-06, Vol.144 (11), p.4275-4283</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-407cdc530c05ff83aaa738c43e52313e74e397b3aea61053b08ee81b7c766a7e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5282625$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2341721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Keefe, TL</creatorcontrib><creatorcontrib>Bandyopadhyay, S</creatorcontrib><creatorcontrib>Datta, SK</creatorcontrib><creatorcontrib>Imanishi-Kari, T</creatorcontrib><title>V region sequences of an idiotypically connected family of pathogenic anti-DNA autoantibodies</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>The H and L chain V region sequences of nine anti-DNA mAb that are representative of a pathogenic population of autoantibodies produced by the nephritis prone (SWR x NZB)F1 (SNF1) mice, were determined. These nine anti-DNA autoantibodies were idiotypically connected members of a cross-reactive Id family called the Id564 cluster. Moreover, these autoantibodies were all cationic in charge, IgG2b in isotype, and their H chain C regions had the normal SWR parent's allotype. Although derived from two different SNF1 animals, these pathogenic autoantibodies possessed highly homologous Leader-VH sequences that could account for their idiotypic cross-reactivity. Furthermore, the VH region sequences of these anti-DNA antibodies contained numerous basic residues that could impart their cationic charge. The Leader-VH sequences of these autoantibodies were also highly homologous to that of an anti-NP antibody-related germ-line gene of C57BL/6 mice, called VH-23. Among these nine pathogenic autoantibodies, three sets of clonally related anti-DNA antibodies could be identified. Thus the Id564 cluster of cationic anti-DNA autoantibodies of SNF1 mice are encoded by highly related VH genes, and this idiotypically connected population of pathogenic autoantibodies are selected to undergo an oligoclonal expansion in the lupus-prone SNF1 mice.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antibodies, Antinuclear - genetics</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blotting, Southern</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Immunoglobulin</subject><subject>Genes. Genome</subject><subject>Immunoglobulin Constant Regions - genetics</subject><subject>Immunoglobulin G - genetics</subject><subject>Immunoglobulin Idiotypes - genetics</subject><subject>Immunoglobulin Variable Region - genetics</subject><subject>Isoelectric Point</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Nephritis - genetics</subject><subject>Nephritis - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rGzEQhkVoSZ2Pf9DCHkrIZd3R9_oYnLYJhOTS9FaEVjtrK-xK7moX439fGbsht-gipHnmHfSIkM8U5gLE4tuL7_spxG5OhZhTOhdMyxMyo1JCqRSoD2QGwFhJtdKfyFlKLwCggIlTcsq4oJrRGfnzuxhw5WMoEv6dMDhMRWwLGwrf-DjuNt7ZrtsVLoaAbsSmaG3v80WGNnZcxxUG7zI_-vL28aaw0xj3hzo2HtMF-djaLuHlcT8nzz--_1relQ9PP--XNw-lk6DHUoB2jZMcHMi2rbi1VvPKCY6SccpRC-QLXXOLVlGQvIYKsaK1dlopq5Gfk6tD7maI-RVpNL1PDrvOBoxTMnqh85LyXZBKJRhTKoPiALohpjRgazaD7-2wMxTMXr_5r99k_YZSs9ef274c86e6x-a16eg7178e6zZlse1gg_PpFZOsYortY64P2Nqv1ls_oEl9_oYcSs12u3078R8WfZ4G</recordid><startdate>19900601</startdate><enddate>19900601</enddate><creator>O'Keefe, TL</creator><creator>Bandyopadhyay, S</creator><creator>Datta, SK</creator><creator>Imanishi-Kari, T</creator><general>Am Assoc Immnol</general><general>American Association of Immunologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19900601</creationdate><title>V region sequences of an idiotypically connected family of pathogenic anti-DNA autoantibodies</title><author>O'Keefe, TL ; Bandyopadhyay, S ; Datta, SK ; Imanishi-Kari, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-407cdc530c05ff83aaa738c43e52313e74e397b3aea61053b08ee81b7c766a7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antibodies, Antinuclear - genetics</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blotting, Southern</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, Immunoglobulin</topic><topic>Genes. Genome</topic><topic>Immunoglobulin Constant Regions - genetics</topic><topic>Immunoglobulin G - genetics</topic><topic>Immunoglobulin Idiotypes - genetics</topic><topic>Immunoglobulin Variable Region - genetics</topic><topic>Isoelectric Point</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Nephritis - genetics</topic><topic>Nephritis - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Keefe, TL</creatorcontrib><creatorcontrib>Bandyopadhyay, S</creatorcontrib><creatorcontrib>Datta, SK</creatorcontrib><creatorcontrib>Imanishi-Kari, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Keefe, TL</au><au>Bandyopadhyay, S</au><au>Datta, SK</au><au>Imanishi-Kari, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>V region sequences of an idiotypically connected family of pathogenic anti-DNA autoantibodies</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1990-06-01</date><risdate>1990</risdate><volume>144</volume><issue>11</issue><spage>4275</spage><epage>4283</epage><pages>4275-4283</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><coden>JOIMA3</coden><abstract>The H and L chain V region sequences of nine anti-DNA mAb that are representative of a pathogenic population of autoantibodies produced by the nephritis prone (SWR x NZB)F1 (SNF1) mice, were determined. These nine anti-DNA autoantibodies were idiotypically connected members of a cross-reactive Id family called the Id564 cluster. Moreover, these autoantibodies were all cationic in charge, IgG2b in isotype, and their H chain C regions had the normal SWR parent's allotype. Although derived from two different SNF1 animals, these pathogenic autoantibodies possessed highly homologous Leader-VH sequences that could account for their idiotypic cross-reactivity. Furthermore, the VH region sequences of these anti-DNA antibodies contained numerous basic residues that could impart their cationic charge. The Leader-VH sequences of these autoantibodies were also highly homologous to that of an anti-NP antibody-related germ-line gene of C57BL/6 mice, called VH-23. Among these nine pathogenic autoantibodies, three sets of clonally related anti-DNA antibodies could be identified. Thus the Id564 cluster of cationic anti-DNA autoantibodies of SNF1 mice are encoded by highly related VH genes, and this idiotypically connected population of pathogenic autoantibodies are selected to undergo an oligoclonal expansion in the lupus-prone SNF1 mice.</abstract><cop>Bethesda, MD</cop><pub>Am Assoc Immnol</pub><pmid>2341721</pmid><doi>10.4049/jimmunol.144.11.4275</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Amino Acid Sequence Animals Antibodies, Antinuclear - genetics Base Sequence Biological and medical sciences Blotting, Southern Fundamental and applied biological sciences. Psychology Genes, Immunoglobulin Genes. Genome Immunoglobulin Constant Regions - genetics Immunoglobulin G - genetics Immunoglobulin Idiotypes - genetics Immunoglobulin Variable Region - genetics Isoelectric Point Mice Molecular and cellular biology Molecular genetics Molecular Sequence Data Nephritis - genetics Nephritis - immunology |
title | V region sequences of an idiotypically connected family of pathogenic anti-DNA autoantibodies |
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