V region sequences of an idiotypically connected family of pathogenic anti-DNA autoantibodies

The H and L chain V region sequences of nine anti-DNA mAb that are representative of a pathogenic population of autoantibodies produced by the nephritis prone (SWR x NZB)F1 (SNF1) mice, were determined. These nine anti-DNA autoantibodies were idiotypically connected members of a cross-reactive Id fa...

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Veröffentlicht in:The Journal of immunology (1950) 1990-06, Vol.144 (11), p.4275-4283
Hauptverfasser: O'Keefe, TL, Bandyopadhyay, S, Datta, SK, Imanishi-Kari, T
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container_issue 11
container_start_page 4275
container_title The Journal of immunology (1950)
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creator O'Keefe, TL
Bandyopadhyay, S
Datta, SK
Imanishi-Kari, T
description The H and L chain V region sequences of nine anti-DNA mAb that are representative of a pathogenic population of autoantibodies produced by the nephritis prone (SWR x NZB)F1 (SNF1) mice, were determined. These nine anti-DNA autoantibodies were idiotypically connected members of a cross-reactive Id family called the Id564 cluster. Moreover, these autoantibodies were all cationic in charge, IgG2b in isotype, and their H chain C regions had the normal SWR parent's allotype. Although derived from two different SNF1 animals, these pathogenic autoantibodies possessed highly homologous Leader-VH sequences that could account for their idiotypic cross-reactivity. Furthermore, the VH region sequences of these anti-DNA antibodies contained numerous basic residues that could impart their cationic charge. The Leader-VH sequences of these autoantibodies were also highly homologous to that of an anti-NP antibody-related germ-line gene of C57BL/6 mice, called VH-23. Among these nine pathogenic autoantibodies, three sets of clonally related anti-DNA antibodies could be identified. Thus the Id564 cluster of cationic anti-DNA autoantibodies of SNF1 mice are encoded by highly related VH genes, and this idiotypically connected population of pathogenic autoantibodies are selected to undergo an oligoclonal expansion in the lupus-prone SNF1 mice.
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subjects Amino Acid Sequence
Animals
Antibodies, Antinuclear - genetics
Base Sequence
Biological and medical sciences
Blotting, Southern
Fundamental and applied biological sciences. Psychology
Genes, Immunoglobulin
Genes. Genome
Immunoglobulin Constant Regions - genetics
Immunoglobulin G - genetics
Immunoglobulin Idiotypes - genetics
Immunoglobulin Variable Region - genetics
Isoelectric Point
Mice
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Nephritis - genetics
Nephritis - immunology
title V region sequences of an idiotypically connected family of pathogenic anti-DNA autoantibodies
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