Study of the British Pharmacopeia method on methimazole (thiamazole) content in carbimazole tablets

The analysis of carbimazole tablets in The British Pharmacopoeia, 1993, includes a quantitative thin layer chromatography (TLC) determination of methimazole. Repeated analysis of the same samples did not give similar results. The repeatability and reproducibility of the method was studied. It was pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1998, Vol.16 (5), p.785-792
Hauptverfasser:	Aletrari, Maria, Kanari, Popi, Partassides, Dora, Loizou, Evdokia
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antithyroid Agents - analysis Biological and medical sciences Carbimazole Carbimazole - chemistry Chromatography, High Pressure Liquid - methods Chromatography, Thin Layer - methods Evaluation Studies as Topic General pharmacology High performance liquid chromatography Medical sciences Methimazole (thiamazole) Methimazole - analysis Pharmacology. Drug treatments Quality Control Reproducibility of Results Tablets - chemistry Thin layer chromatography
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The analysis of carbimazole tablets in The British Pharmacopoeia, 1993, includes a quantitative thin layer chromatography (TLC) determination of methimazole. Repeated analysis of the same samples did not give similar results. The repeatability and reproducibility of the method was studied. It was proved that the residence time of the methimazole spot on the TLC plate is time dependent.
ISSN:	0731-7085 1873-264X
DOI:	10.1016/S0731-7085(97)00119-2