New trends in photobiology the interaction of UVA radiation with cultured cells

Recent work concerning the interaction of UVA radiation (320 – 380 nm) with cultured cells is reviewed with particular emphasis on the involvement of cellular oxidative stress in the biological effects of this radiation on eucaryotic cells. Possible chromophores are considered and their role in gene...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of Photochemistry & Photobiology, B: Biology B: Biology, 1990-03, Vol.4 (4), p.349-361
Hauptverfasser:	Tyrrell, R.M., Keyse, S.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antioxidant enzymes Antioxidants - metabolism Biological and medical sciences Cell physiology Cells, Cultured DNA - radiation effects DNA Repair - radiation effects Effects of physical and chemical agents Free Radicals Fundamental and applied biological sciences. Psychology Heme Oxygenase (Decyclizing) - radiation effects Humans Membranes - radiation effects Molecular and cellular biology oxidative stress Oxygen - radiation effects photoprotection Ultraviolet Rays - adverse effects UVA
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Recent work concerning the interaction of UVA radiation (320 – 380 nm) with cultured cells is reviewed with particular emphasis on the involvement of cellular oxidative stress in the biological effects of this radiation on eucaryotic cells. Possible chromophores are considered and their role in generation of various oxidant species including hydrogen peroxide, superoxide anion, singlet oxygen and hydroxyl radical. DNA and membranes are discussed as possible targets for the lethal action of long wavelength radiation. Four mechanisms of cellular defence are proposed: (1) DNA repair; (2) antioxidant enzymes; (3) endogenous free radical quenchers; (4) inducible protection.
ISSN:	1011-1344 1873-2682
DOI:	10.1016/1011-1344(90)85014-N