Routine production of 2-deoxy-2-[ 18F]fluoro- d-glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin

Routine production of 2-deoxy-2-[ 18F]fluoro- d-glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin

Resin-supported [ 18F]fluoride ion has been prepared and applied to a rapid, convenient synthesis of [ 18F]FDG. “No-carrier-added” [ 18F]fluoride ion is collected on a quaternary 4-( N, N-dialkylamino)-pyridinium functionalized polystyrene anion exchange resin directly from a [ 18O]water target, dri...

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Veröffentlicht in:International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Nuclear medicine and biology, 1990, Vol.17 (3), p.273-279
Hauptverfasser: Toorongian, Steven A., Mulholland, G.Keith, Jewett, Douglas M., Bachelor, Michael A., Kilbourn, Michael R.
Format: Artikel
Sprache:eng
Schlagworte:
Anion Exchange Resins
Biological and medical sciences
Deoxy Sugars
Deoxyglucose - analogs & derivatives
Fluorine Radioisotopes
Fluorodeoxyglucose F18
Investigative techniques, diagnostic techniques (general aspects)
Isotope Labeling - methods
Medical sciences
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Zusammenfassung:Resin-supported [ 18F]fluoride ion has been prepared and applied to a rapid, convenient synthesis of [ 18F]FDG. “No-carrier-added” [ 18F]fluoride ion is collected on a quaternary 4-( N, N-dialkylamino)-pyridinium functionalized polystyrene anion exchange resin directly from a [ 18O]water target, dried by rinsing with acetonitrile, and then reacted with 1,3,4,6-tetra- O-acetyl-2- O-trifluoromethanesulfonyl-β- d-mannopyrannose. Acidic hydrolysis yields [ 18F]FDG in a synthesis time of 40 min with overall yields presently averaging above 50%.
ISSN:0883-2897
DOI:10.1016/0883-2897(90)90052-3