A Novel Long-Acting VIP Analog in the Guinea Pig Trachea In Vitro

Yoshihara, S., A. Lindén, K. Kashimoto and S. Watanabe. A long-acting novel VIP analog in the guinea pig trachea in vitro. Peptides 19(3) 593–597, 1998.—The relaxant effect of a novel VIP analog, [Arg 15,20,21Leu 17]-VIP-Gly-Lys-Arg-NH 2 was compared with that of the original VIP in the same guinea...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1998, Vol.19 (3), p.593-597
Hauptverfasser:	Yoshihara, Shigemi, Lindén, Anders, Kashimoto, Kazuhisa, Watanabe, Shigeaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuterol - pharmacology Amino Acid Sequence Animals Bronchodilator Captopril - pharmacology Carbachol - pharmacology Guinea pig airways Guinea Pigs Male Molecular Sequence Data Muscle Relaxation - drug effects Neuropeptides Peptidase Smooth muscle relaxation Structure-Activity Relationship Time Factors Trachea - drug effects Vasoactive Intestinal Peptide - analogs & derivatives Vasoactive Intestinal Peptide - chemistry Vasoactive Intestinal Peptide - metabolism Vasoactive Intestinal Peptide - pharmacology VIP VIP analog
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Zusammenfassung:	Yoshihara, S., A. Lindén, K. Kashimoto and S. Watanabe. A long-acting novel VIP analog in the guinea pig trachea in vitro. Peptides 19(3) 593–597, 1998.—The relaxant effect of a novel VIP analog, [Arg 15,20,21Leu 17]-VIP-Gly-Lys-Arg-NH 2 was compared with that of the original VIP in the same guinea pig trachea precontracted by carbachol in vitro. The VIP analog caused significantly and concentration-dependent relaxation similarily to the original VIP. In contrast to the original VIP, the VIP analog demonstrated a slow onset and offset of action, with more than 90% of its maximum relaxation remaining 6 h after administration. Peptidase inhibition by captopril and phosphoramidon increased the relaxant effect and duration of action for original VIP but not for the VIP analog.
ISSN:	0196-9781 1873-5169
DOI:	10.1016/S0196-9781(97)00457-9