Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA

Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA

Human papilloma virus (HPV) DNA sequences (HPV types 16,18, 33, 35 or uncharacterised) were detected by Southern blot hybridisation and polymerase chain reaction in 84% of 106 early-stage invasive carcinomas of the uterine cervix. Among HPV-positive patients, the risk of overall relapse did not diff...

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Veröffentlicht in:The Lancet (British edition) 1990-05, Vol.335 (8699), p.1171-1174
Hauptverfasser: Riou, G., Bourhis, J., Favre, M., Orth, G., Jeannel, D., Le Doussal, V.
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma - analysis
Adenocarcinoma - pathology
Adult
Analysis of Variance
Biological and medical sciences
Cancer
Carcinoma, Squamous Cell - analysis
Carcinoma, Squamous Cell - pathology
Deoxyribonucleic acid
DNA
DNA Probes
DNA, Viral - analysis
Evaluation Studies as Topic
Female
Follow-Up Studies
Gynecology. Andrology. Obstetrics
Humans
Lymphatic Metastasis
Medical research
Medical sciences
Middle Aged
Neoplasm Recurrence, Local - analysis
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Papillomaviridae - classification
Papillomaviridae - genetics
Polymerase Chain Reaction
Prognosis
Reproductive system
Risk Factors
Survival
Uterine Cervical Neoplasms - analysis
Uterine Cervical Neoplasms - pathology
Viruses
Women
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Beschreibung
Zusammenfassung:Human papilloma virus (HPV) DNA sequences (HPV types 16,18, 33, 35 or uncharacterised) were detected by Southern blot hybridisation and polymerase chain reaction in 84% of 106 early-stage invasive carcinomas of the uterine cervix. Among HPV-positive patients, the risk of overall relapse did not differ with individual HPV types. Compared with HPV-positive patients, those with no detectable HPV DNA had a 2·6 times higher risk of overall relapse (p
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(90)92693-C