Effect of cumene hydroperoxide or hypoxia-reoxygenation on glutathione status in guinea-pig heart

Hypoxia-reoxygenation induces oxidative damage. To examine the mechanism by which oxidative injury occurs, cumene-hydroperoxide was used in the guinea-pig heart. Guinea-pig heart was selected because while it is devoid of selenium dependent glutathione peroxidase activity it possesses selenium indep...

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Veröffentlicht in:	Biochemical pharmacology 1990-05, Vol.39 (10), p.1617-1620
Hauptverfasser:	Baccaro, Cecilia, Brunori, Maurizio, Di Simplicio, Paolo, Fazzini, Alessandro, Franconi, Flavia, Giotti, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzene Derivatives - pharmacology Biological and medical sciences Cardiology. Vascular system Coronary heart disease Glutaredoxins glutathione Glutathione - analogs & derivatives Glutathione - metabolism Glutathione Disulfide Glutathione Reductase - analysis Glutathione Transferase - analysis Guinea Pigs Heart Heart - drug effects Hypoxia - metabolism L-Lactate Dehydrogenase - analysis Medical sciences Myocardium - enzymology Oxidoreductases - analysis Oxygen - metabolism Perfusion Protein Disulfide Reductase (Glutathione)
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Zusammenfassung:	Hypoxia-reoxygenation induces oxidative damage. To examine the mechanism by which oxidative injury occurs, cumene-hydroperoxide was used in the guinea-pig heart. Guinea-pig heart was selected because while it is devoid of selenium dependent glutathione peroxidase activity it possesses selenium independent activity, known as glutathione transferase of class alpha.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/0006-2952(90)90530-X