Novel Lactone Compounds from Mortierella verticillata that Induce the Human Low Density Lipoprotein Receptor Gene:Fermentation, Isolation, Structural Elucidation and Biological Activities

Among methods of controlling hypercholesterolemia and hyperlipidemia is the direct stimulation of hepatic low density lipoprotein (LDL) receptors. Two novel lactone compounds, CJ-12, 950 and CJ-13, 357, containing an unusual oxime moiety, were isolated from a zygomycete Mortierella verticillata. The...

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Veröffentlicht in:	Journal of antibiotics 1998/01/25, Vol.51(1), pp.14-20
Hauptverfasser:	DEKKER, KOEN A., AIELLO, ROBERT J., HIRAI, HIDEO, INAGAKI, TAISUKE, SAKAKIBARA, TATSUO, SUZUKI, YUMIKO, THOMPSON, JOHN F., YAMAUCHI, YUJI, KOJIMA, NAKAO
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Culture Techniques Fermentation Gene Expression Regulation General and cellular metabolism. Vitamins Humans Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology Macrolides - chemistry Macrolides - isolation & purification Macrolides - pharmacology Medical sciences Mucorales - chemistry Mucorales - metabolism Pharmacology. Drug treatments Receptors, LDL - genetics
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Zusammenfassung:	Among methods of controlling hypercholesterolemia and hyperlipidemia is the direct stimulation of hepatic low density lipoprotein (LDL) receptors. Two novel lactone compounds, CJ-12, 950 and CJ-13, 357, containing an unusual oxime moiety, were isolated from a zygomycete Mortierella verticillata. These lactones are potent inducers of the LDL receptor gene in vitro, that enhanced LDL receptor expression in human hepatocytes 2-fold at 100nM.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.51.14