Genetic Linkage Is Excluded for the D₂-Dopamine Receptor λHD2G1 and Flanking Loci on Chromosome 11q22-q23 in Tourette Syndrome

Genetic Linkage Is Excluded for the D₂-Dopamine Receptor λHD2G1 and Flanking Loci on Chromosome 11q22-q23 in Tourette Syndrome

A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D₂-dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to ±20% recombination were...

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Veröffentlicht in:Human heredity 1990, Vol.40 (2), p.105-108
Hauptverfasser: Devor, Eric J., Grandy, David K., Civelli, Olivier, Litt, Michael, Burgess, Andrea K., Isenberg, Keith E., van de Wetering, B.J.M., Oostra, Ben
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Chromosomes, Human, Pair 11
DNA Probes
Female
Genetic Linkage
Humans
Lod Score
Male
Medical sciences
Neurology
Original Papers
Receptors, Dopamine - genetics
Tourette Syndrome - genetics
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Beschreibung
Zusammenfassung:A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D₂-dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to ±20% recombination were obtained. Overlapping regions of exclusion based upon primary map data permit exclusion of the entire region of the DRD2 locus in Tourette syndrome.
ISSN:0001-5652
1423-0062
DOI:10.1159/000153914