Organization of the Human and Mouse Low-Affinity FcγR Genes: Duplication and Recombination

Receptors for immunoglobulin G immune complexes (FcγRII and FcγRIII) are expressed on most hematopoietic cells and show much structural and functional diversity. In order to determine the genetic basis for this diversity, a family of genes encoding the human and mouse receptors was isolated and char...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1990-05, Vol.248 (4956), p.732-735
Hauptverfasser:	Qiu, Wei Qiao, De Bruin, Derik, Brownstein, Bernard H., Pearse, Roger, Ravetch, Jeffrey V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen antibody complex Antigens, Differentiation - genetics Antigens, Differentiation - metabolism Base Sequence Biological and medical sciences Blotting, Southern DNA DNA probes Exons Fundamental and applied biological sciences. Psychology Gels Genes Genes. Genome Genetic loci Genome, Human Good til cancelled Humans immunoglobulin G Immunoglobulin G - metabolism Introns Mice Molecular and cellular biology Molecular genetics Molecular Sequence Data Multigene Family Mutation Receptors Receptors, Fc - genetics Receptors, Fc - metabolism Receptors, IgG Recombination, Genetic Restriction Mapping Spleen Spleen - immunology
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Beschreibung
Zusammenfassung:	Receptors for immunoglobulin G immune complexes (FcγRII and FcγRIII) are expressed on most hematopoietic cells and show much structural and functional diversity. In order to determine the genetic basis for this diversity, a family of genes encoding the human and mouse receptors was isolated and characterized. Humans have five distinct genes for low-affinity FcγRs, in contrast to two in the mouse. With the use of yeast artificial chromosomes, the genes encoding the human receptors were oriented and linked, which established the structure of this complex locus. Comparison of the human and mouse genes generated a model for the evolutionary amplification of this locus.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.2139735