Does a 2 ← 5β-turn structure exist in enkephalins?: Study of a fully protected Leu-enkephalin in organic solution by 17O-NMR

Does a 2 ← 5β-turn structure exist in enkephalins?: Study of a fully protected Leu-enkephalin in organic solution by 17O-NMR

The 17O chemical shifts of the Gly-2 and Gly-3 oxygens of a fully protected Leu-enkephalin were measured to be identical in acetone solution. This allows the conclusion that neither of these peptide oxygens is hydrogen bonded and that no specific 2 ← 5 β-turn structure exists to an appreciable exten...

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Veröffentlicht in:FEBS letters 1990-03, Vol.262 (2), p.173-175
Hauptverfasser: Moret, E., Gerothanassis, I.P., Hunston, R.N., Lauterwein, J.
Format: Artikel
Sprache:eng
Schlagworte:
17O-NMR
Aminoacids, peptides. Hormones. Neuropeptides
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Chemical Phenomena
Chemistry
Enkephalin
Enkephalin, Leucine
Fundamental and applied biological sciences. Psychology
Glycine
Hydrogen Bonding
Magnetic Resonance Spectroscopy - methods
Oxygen Isotopes
Protein Conformation
Proteins
β-Turn structure
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Beschreibung
Zusammenfassung:The 17O chemical shifts of the Gly-2 and Gly-3 oxygens of a fully protected Leu-enkephalin were measured to be identical in acetone solution. This allows the conclusion that neither of these peptide oxygens is hydrogen bonded and that no specific 2 ← 5 β-turn structure exists to an appreciable extent.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(90)80182-I