A comparative study of elastic properties of rat and guinea pig parenchymal strips
Constricted guinea pig (GP) airways are much less sensitive to changes in transpulmonary pressure (Ptp) than are those of the rat. The object of this study was to investigate whether differences in the mechanical behavior of the lung parenchyma could explain differences between the two species in th...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 1998-03, Vol.157 (3), p.846-852 |
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| container_title | American journal of respiratory and critical care medicine |
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| creator | SALERNO, F. G PARE, P LUDWIG, M. S |
| description | Constricted guinea pig (GP) airways are much less sensitive to changes in transpulmonary pressure (Ptp) than are those of the rat. The object of this study was to investigate whether differences in the mechanical behavior of the lung parenchyma could explain differences between the two species in the interdependence of the airway and parenchyma. Subpleural lung strips from guinea pigs and rats were excised and suspended in an organ bath. One end of each strip was attached to a force transducer and the other to a servo-controlled lever arm that effected length (L) changes in the strip. Sinusoidal oscillations at varying frequencies and amplitudes were applied at different resting tensions. Measurements of L and resting tension (T) were recorded during baseline conditions and after acetylcholine (ACh) challenge. Elastance (E) and resistance (R) were calculated by fitting changes in T and L to the equation of motion. During sinusoidal oscillations, E and R in the two species were different in both the unconstricted and constricted states. The effect of T on E was significantly different in rats and GPs; E was less dependent on T in GPs. Insofar as E is a measure of the load against which airway smooth muscle (ASM) contracts, this difference may represent a potential mechanism to explain why constricted GP airways are less sensitive to changes in Ptp. |
| doi_str_mv | 10.1164/ajrccm.157.3.9705078 |
| format | Article |
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G ; PARE, P ; LUDWIG, M. S</creator><creatorcontrib>SALERNO, F. G ; PARE, P ; LUDWIG, M. S</creatorcontrib><description>Constricted guinea pig (GP) airways are much less sensitive to changes in transpulmonary pressure (Ptp) than are those of the rat. The object of this study was to investigate whether differences in the mechanical behavior of the lung parenchyma could explain differences between the two species in the interdependence of the airway and parenchyma. Subpleural lung strips from guinea pigs and rats were excised and suspended in an organ bath. One end of each strip was attached to a force transducer and the other to a servo-controlled lever arm that effected length (L) changes in the strip. Sinusoidal oscillations at varying frequencies and amplitudes were applied at different resting tensions. Measurements of L and resting tension (T) were recorded during baseline conditions and after acetylcholine (ACh) challenge. Elastance (E) and resistance (R) were calculated by fitting changes in T and L to the equation of motion. During sinusoidal oscillations, E and R in the two species were different in both the unconstricted and constricted states. The effect of T on E was significantly different in rats and GPs; E was less dependent on T in GPs. Insofar as E is a measure of the load against which airway smooth muscle (ASM) contracts, this difference may represent a potential mechanism to explain why constricted GP airways are less sensitive to changes in Ptp.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/ajrccm.157.3.9705078</identifier><identifier>PMID: 9517601</identifier><language>eng</language><publisher>New York, NY: American Lung Association</publisher><subject>Acetylcholine - pharmacology ; Adrenergic beta-Agonists - pharmacology ; Air breathing ; Animals ; Biological and medical sciences ; Bronchi - anatomy & histology ; Bronchi - drug effects ; Bronchi - physiology ; Bronchoconstriction - physiology ; Bronchodilator Agents - pharmacology ; Elasticity ; Fundamental and applied biological sciences. Psychology ; Guinea Pigs ; Isoproterenol - pharmacology ; Lung - anatomy & histology ; Lung - drug effects ; Lung - physiology ; Male ; Muscle Contraction - drug effects ; Muscle Contraction - physiology ; Muscle, Smooth - anatomy & histology ; Muscle, Smooth - drug effects ; Muscle, Smooth - physiology ; Pressure ; Rats ; Rats, Sprague-Dawley ; Respiratory Mechanics - physiology ; Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics ; Space life sciences ; Stress, Mechanical ; Transducers ; Vertebrates: respiratory system ; Viscosity</subject><ispartof>American journal of respiratory and critical care medicine, 1998-03, Vol.157 (3), p.846-852</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-e0259b81a58211d856cc5f8197a9d20a448df4ee6b609c89df8190dbfb2b81d53</citedby><cites>FETCH-LOGICAL-c377t-e0259b81a58211d856cc5f8197a9d20a448df4ee6b609c89df8190dbfb2b81d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4025,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2173663$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9517601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SALERNO, F. G</creatorcontrib><creatorcontrib>PARE, P</creatorcontrib><creatorcontrib>LUDWIG, M. S</creatorcontrib><title>A comparative study of elastic properties of rat and guinea pig parenchymal strips</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Constricted guinea pig (GP) airways are much less sensitive to changes in transpulmonary pressure (Ptp) than are those of the rat. The object of this study was to investigate whether differences in the mechanical behavior of the lung parenchyma could explain differences between the two species in the interdependence of the airway and parenchyma. Subpleural lung strips from guinea pigs and rats were excised and suspended in an organ bath. One end of each strip was attached to a force transducer and the other to a servo-controlled lever arm that effected length (L) changes in the strip. Sinusoidal oscillations at varying frequencies and amplitudes were applied at different resting tensions. Measurements of L and resting tension (T) were recorded during baseline conditions and after acetylcholine (ACh) challenge. Elastance (E) and resistance (R) were calculated by fitting changes in T and L to the equation of motion. During sinusoidal oscillations, E and R in the two species were different in both the unconstricted and constricted states. The effect of T on E was significantly different in rats and GPs; E was less dependent on T in GPs. Insofar as E is a measure of the load against which airway smooth muscle (ASM) contracts, this difference may represent a potential mechanism to explain why constricted GP airways are less sensitive to changes in Ptp.</description><subject>Acetylcholine - pharmacology</subject><subject>Adrenergic beta-Agonists - pharmacology</subject><subject>Air breathing</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bronchi - anatomy & histology</subject><subject>Bronchi - drug effects</subject><subject>Bronchi - physiology</subject><subject>Bronchoconstriction - physiology</subject><subject>Bronchodilator Agents - pharmacology</subject><subject>Elasticity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guinea Pigs</subject><subject>Isoproterenol - pharmacology</subject><subject>Lung - anatomy & histology</subject><subject>Lung - drug effects</subject><subject>Lung - physiology</subject><subject>Male</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle Contraction - physiology</subject><subject>Muscle, Smooth - anatomy & histology</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - physiology</subject><subject>Pressure</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Respiratory Mechanics - physiology</subject><subject>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</subject><subject>Space life sciences</subject><subject>Stress, Mechanical</subject><subject>Transducers</subject><subject>Vertebrates: respiratory system</subject><subject>Viscosity</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEYRYMotVb_gUIW4m5qMkkmybIUX1AQRMFdyCSZmjIvkxmh_96UDl3lce_5-DgA3GK0xLigj3oXjGmWmPElWUqOGOLiDMwxIyyj6X2e7oiTjFL5fQmuYtwhhHOB0QzMJMO8QHgOPlbQdE2vgx78n4NxGO0edhV0tY6DN7APXe_C4F08_KYW1K2F29G3TsPeb2FCXWt-9o2uEx18H6_BRaXr6G6mcwG-np8-16_Z5v3lbb3aZIZwPmQO5UyWAmsmcoytYIUxrBJYci1tjjSlwlbUuaIskDRC2kOGbFmVeaIsIwvwcJybdvwdXRxU46Nxda1b141Rcckp4zxPRXosmtDFGFyl-uAbHfYKI3VQqY4qVVKpiJpUJuxumj-WjbMnaHKX8vsp19Hougq6NT6eajnmpCgI-QdGLX5i</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>SALERNO, F. G</creator><creator>PARE, P</creator><creator>LUDWIG, M. S</creator><general>American Lung Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980301</creationdate><title>A comparative study of elastic properties of rat and guinea pig parenchymal strips</title><author>SALERNO, F. G ; PARE, P ; LUDWIG, M. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-e0259b81a58211d856cc5f8197a9d20a448df4ee6b609c89df8190dbfb2b81d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Adrenergic beta-Agonists - pharmacology</topic><topic>Air breathing</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bronchi - anatomy & histology</topic><topic>Bronchi - drug effects</topic><topic>Bronchi - physiology</topic><topic>Bronchoconstriction - physiology</topic><topic>Bronchodilator Agents - pharmacology</topic><topic>Elasticity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guinea Pigs</topic><topic>Isoproterenol - pharmacology</topic><topic>Lung - anatomy & histology</topic><topic>Lung - drug effects</topic><topic>Lung - physiology</topic><topic>Male</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle Contraction - physiology</topic><topic>Muscle, Smooth - anatomy & histology</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - physiology</topic><topic>Pressure</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Respiratory Mechanics - physiology</topic><topic>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</topic><topic>Space life sciences</topic><topic>Stress, Mechanical</topic><topic>Transducers</topic><topic>Vertebrates: respiratory system</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SALERNO, F. G</creatorcontrib><creatorcontrib>PARE, P</creatorcontrib><creatorcontrib>LUDWIG, M. S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SALERNO, F. G</au><au>PARE, P</au><au>LUDWIG, M. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative study of elastic properties of rat and guinea pig parenchymal strips</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>157</volume><issue>3</issue><spage>846</spage><epage>852</epage><pages>846-852</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Constricted guinea pig (GP) airways are much less sensitive to changes in transpulmonary pressure (Ptp) than are those of the rat. The object of this study was to investigate whether differences in the mechanical behavior of the lung parenchyma could explain differences between the two species in the interdependence of the airway and parenchyma. Subpleural lung strips from guinea pigs and rats were excised and suspended in an organ bath. One end of each strip was attached to a force transducer and the other to a servo-controlled lever arm that effected length (L) changes in the strip. Sinusoidal oscillations at varying frequencies and amplitudes were applied at different resting tensions. Measurements of L and resting tension (T) were recorded during baseline conditions and after acetylcholine (ACh) challenge. Elastance (E) and resistance (R) were calculated by fitting changes in T and L to the equation of motion. During sinusoidal oscillations, E and R in the two species were different in both the unconstricted and constricted states. The effect of T on E was significantly different in rats and GPs; E was less dependent on T in GPs. Insofar as E is a measure of the load against which airway smooth muscle (ASM) contracts, this difference may represent a potential mechanism to explain why constricted GP airways are less sensitive to changes in Ptp.</abstract><cop>New York, NY</cop><pub>American Lung Association</pub><pmid>9517601</pmid><doi>10.1164/ajrccm.157.3.9705078</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload; American Thoracic Society (ATS) Journals Online |
| subjects | Acetylcholine - pharmacology Adrenergic beta-Agonists - pharmacology Air breathing Animals Biological and medical sciences Bronchi - anatomy & histology Bronchi - drug effects Bronchi - physiology Bronchoconstriction - physiology Bronchodilator Agents - pharmacology Elasticity Fundamental and applied biological sciences. Psychology Guinea Pigs Isoproterenol - pharmacology Lung - anatomy & histology Lung - drug effects Lung - physiology Male Muscle Contraction - drug effects Muscle Contraction - physiology Muscle, Smooth - anatomy & histology Muscle, Smooth - drug effects Muscle, Smooth - physiology Pressure Rats Rats, Sprague-Dawley Respiratory Mechanics - physiology Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Space life sciences Stress, Mechanical Transducers Vertebrates: respiratory system Viscosity |
| title | A comparative study of elastic properties of rat and guinea pig parenchymal strips |
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