Pharmacological Activity of Angiotensin-II Modified by Tyrosine Sulfation

An angiotensin-II analogue with a sulfated tyrosine residue was prepared by arylsulfotransferase treatment of synthetic human angjotensin-II. Its biological activities were studied in isolated smooth muscles, and its effect on blood pressure was determined. The sulfated angiotensin-II (All-S) was ab...

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Veröffentlicht in:	Japanese Journal of Pharmacology 1990, Vol.52(3), pp.493-495
Hauptverfasser:	HAGIWARA, Masaki, OHUCHI, Eiko, HONGO, Kazuya, OKI, Miyuki, WADA, Koichi, MORIKAWA, Tadanori, KOBASHI, Kyoichi
Format:	Artikel
Sprache:	eng
Schlagworte:	angiotensin II Angiotensin II - analogs & derivatives Angiotensin II - analysis Angiotensin II - pharmacology Animals Arylsulfotransferase - metabolism Biological and medical sciences blood pressure Cardiovascular system Gallbladder - drug effects Guinea Pigs Ileum - drug effects In Vitro Techniques Male Medical sciences Miscellaneous Muscle Contraction - drug effects Muscle, Smooth - drug effects Pharmacology. Drug treatments Rats Sulfates tyrosine Tyrosine - analogs & derivatives
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Zusammenfassung:	An angiotensin-II analogue with a sulfated tyrosine residue was prepared by arylsulfotransferase treatment of synthetic human angjotensin-II. Its biological activities were studied in isolated smooth muscles, and its effect on blood pressure was determined. The sulfated angiotensin-II (All-S) was about 15-30 fold less potent than angjotensin-II (All) for ileum contraction and gallbladder contraction. The hypertensive potency of AII-S was about 30-fold less than that of All.
ISSN:	0021-5198 1347-3506
DOI:	10.1254/jjp.52.493