Sera from MS patients and normal controls opsonize myelin

Sera from MS patients and normal controls opsonize myelin

Fc receptor-dependent myelin phagocytosis has been proposed as a mechanism of demyelination in multiple sclerosis (MS). The object of this study was to determine whether MS patients' sera are more opsonic for myelin than normal controls' sera. Opsonization was tested by culturing thioglyco...

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Veröffentlicht in:Neuroscience letters 1990-02, Vol.109 (3), p.353-356
Hauptverfasser: Goldenberg, Perry Z., Troiano, Ray A., Kwon, Eunice E., Prineas, John W.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Biological Factors - immunology
Cattle
Female
Humans
In Vitro Techniques
Macrophage Activation
Medical sciences
Mice
Mice, Inbred DBA
Multiple sclerosis
Multiple Sclerosis - immunology
Multiple Sclerosis - physiopathology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Myelin
Myelin Sheath - immunology
Neurology
Opsonin
Opsonin Proteins
Phagocytosis
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Zusammenfassung:Fc receptor-dependent myelin phagocytosis has been proposed as a mechanism of demyelination in multiple sclerosis (MS). The object of this study was to determine whether MS patients' sera are more opsonic for myelin than normal controls' sera. Opsonization was tested by culturing thioglycollate elicited murine peritoneal macrophages with 125I-labelled, serum-sensitized bovine central myelin. The two groups of sera were found to opsonize myelin equally well after 30 and 120 min incubations. We conclude that MS patients' sera are not more opsonic for myelin than sera from normal controls.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(90)90021-Z