Ethanol and the NMDA receptor

The actions of glutamate, the major excitatory amino acid in the CNS, are mediated by three receptor subtypes: kainate, quisqualate and N-methyl-D-aspartate (NMDA) receptors. Ethanol, in vitro, is a potent and selective inhibitor of the actions of agonists at the NMDA receptor. Following chronic eth...

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Veröffentlicht in:	Alcohol (Fayetteville, N.Y.) N.Y.), 1990-05, Vol.7 (3), p.229-231
Hauptverfasser:	Hoffman, Paula L., Rabe, Carolyn S., Grant, Kathleen A., Valverius, Peter, Hudspith, Michael, Tabakoff, Boris
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Calcium influx Cyclic GMP Ethanol Ethanol - pharmacology Ethanol withdrawal seizures Glutamate Humans Medical sciences MK-801 binding NMDA receptor Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter - metabolism Toxicology
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Beschreibung
Zusammenfassung:	The actions of glutamate, the major excitatory amino acid in the CNS, are mediated by three receptor subtypes: kainate, quisqualate and N-methyl-D-aspartate (NMDA) receptors. Ethanol, in vitro, is a potent and selective inhibitor of the actions of agonists at the NMDA receptor. Following chronic ethanol ingestion, the number of NMDA receptor-ion channel complexes in certain brain areas is increased. This increase may contribute to the generation of ethanol withdrawal seizures, since administration of an NMDA receptor antagonist can reduce these seizures. The results suggest that certain acute behavioral effects of ethanol, such as effects on memory, as well as certain aspects of ethanol withdrawal, may involve the NMDA receptor.
ISSN:	0741-8329 1873-6823
DOI:	10.1016/0741-8329(90)90010-A