The pharmacokinetics of tricyclic antidepressant drugs in the elderly

Antidepressants, especially tricyclic agents (TCAs), are increasingly used in geriatric patients since depression is a common mood disorder in the elderly and the size of elderly population is increasing. Notwithstanding the importance of kinetics to better use of drugs, its study in the elderly (re...

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Veröffentlicht in:	Pharmacological research 1990, Vol.22 (1), p.15-25
Hauptverfasser:	Furlanut, M., Benetello, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antidepressive Agents, Tricyclic - metabolism Antidepressive Agents, Tricyclic - pharmacokinetics Antidepressive Agents, Tricyclic - therapeutic use Biological and medical sciences Biological Availability Depression - drug therapy elderly Humans kinetics Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology tricyclic antidepressants
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Beschreibung
Zusammenfassung:	Antidepressants, especially tricyclic agents (TCAs), are increasingly used in geriatric patients since depression is a common mood disorder in the elderly and the size of elderly population is increasing. Notwithstanding the importance of kinetics to better use of drugs, its study in the elderly (regarding WAS) is not sufficiently developed. The present paper briefly reviews the available data on amitriptyline, nortriptyline, protriptyline, imipramine, desipramine and clomipramine kinetics in the elderly.
ISSN:	1043-6618 1096-1186
DOI:	10.1016/1043-6618(90)90739-Z