A plasmid-mediated beta-lactamase conferring resistance to cefotaxime in a Salmonella typhimurium clone found in St Petersburg, Russia

A plasmid-mediated beta-lactamase conferring resistance to cefotaxime in a Salmonella typhimurium clone found in St Petersburg, Russia

Four clinical and two environmental isolates of cefotaxime-resistant Salmonella typhimurium strains collected in St Petersburg, Russia, were studied. Molecular typing demonstrated that they constituted a single clone. The isolates expressed a cefotaxime-hydrolysing beta-lactamase with a pl of 8.4. T...

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Veröffentlicht in:Journal of antimicrobial chemotherapy 1998-01, Vol.41 (1), p.119-121
Hauptverfasser: Gazouli, M, Sidorenko, S V, Tzelepi, E, Kozlova, N S, Gladin, D P, Tzouvelekis, L S
Format: Artikel
Sprache:eng
Schlagworte:
beta-Lactamases - drug effects
beta-Lactamases - metabolism
Cefotaxime - pharmacology
Cephalosporins - pharmacology
Plasmids - genetics
Russia
Salmonella typhimurium - drug effects
Salmonella typhimurium - enzymology
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Zusammenfassung:Four clinical and two environmental isolates of cefotaxime-resistant Salmonella typhimurium strains collected in St Petersburg, Russia, were studied. Molecular typing demonstrated that they constituted a single clone. The isolates expressed a cefotaxime-hydrolysing beta-lactamase with a pl of 8.4. The enzyme was encoded by a 12 kb plasmid which did not hybridize with TEM, SHV or ampC probes.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/41.1.119