Synthesis and biological evaluation of prodrugs of zidovudine

A series of prodrugs of zidovudine (AZT) has been synthesized in an effort to enhance the uptake of the prodrugs by the HIV-1 infected cells and to increase the plasma half-life of AZT. The 5'-OH function of AZT was esterified with various acids in the presence of DCC and 4-(dimethylamino)pyrid...

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Veröffentlicht in:	Journal of medicinal chemistry 1990-05, Vol.33 (5), p.1505-1510
Hauptverfasser:	Aggarwal, Sunil K, Gogu, Sudhir R, Rangan, S. R. S, Agrawal, Krishna C
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemical synthesis Biological and medical sciences Chemical Phenomena Chemistry HIV - drug effects Humans Medical sciences Microsomes, Liver - drug effects Pharmacology. Drug treatments Prodrugs - chemical synthesis Rats Structure-Activity Relationship Virus Replication - drug effects Zidovudine - pharmacokinetics Zidovudine - pharmacology
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