Enteral nutrition for patients with cystic fibrosis: Comparison of a semi-elemental and nonelemental formula
Objective: To determine whether differences in tolerance and absorption of fat and nitrogen exist between a semi-elemental nutritional formula without enzyme replacement and a nonelemental formula with enzyme replacement. Study design: Sixteen patients (eight girls and eight boys) with cystic fibros...
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Veröffentlicht in: | The Journal of pediatrics 1998-02, Vol.132 (2), p.265-269 |
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Zusammenfassung: | Objective: To determine whether differences in tolerance and absorption of fat and nitrogen exist between a semi-elemental nutritional formula without enzyme replacement and a nonelemental formula with enzyme replacement.
Study design: Sixteen patients (eight girls and eight boys) with cystic fibrosis, 4 to 20 years of age (12 ± 1.3, mean ± SEM), who were pancreatic insufficient completed two 6-day regimens of nocturnal continuous enteral feedings offered in random order. Forty-four percent of the total daily energy was consumed as enteral tube feedings, and the remaining oral dietary intake remained constant throughout the study. Seventy-two–hour fecal collections from each study period were analyzed for total fat, long-chain fatty acids (LCFAs), medium-chain fatty acids (MCFAs), and nitrogen.
Results: Fat absorption was 80.2% ± 2.9% and 82.3% ± 3.1% (
p = 0.58) for the semi-elemental and nonelemental formulas, respectively. Similarly, the coefficient of absorption of LCFAs was 69.5% ± 4.5% and 79.6% ± 3.4% (
p = 0.30) for the semi-elemental and nonelemental formulas. Malabsorption of MCFAs contributed minimally to total fat malabsorption. There was no difference between formulas for MCFA or for nitrogen absorption, 83.7% ± 1.9% and 87.4% ± 1.4%,
p = 0.48. All patients tolerated all feedings, and weight gained was 1.8 ± 0.3 kg with no difference in weight gain between the trials.
Conclusion: A nonelemental formula, with enzyme replacement, is absorbed as well as a predigested formula in patients with CF who are pancreatic insufficient. (J Pediatr 1998;132:265-9) |
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ISSN: | 0022-3476 1097-6833 |
DOI: | 10.1016/S0022-3476(98)70443-3 |