THE MYASTHENIC SYNDROME: ANAESTHESIA IN A PATIENT TREATED WITH 3.4 DIAMINOPYRIDINE
A case of anaesthesia in a patient with myasthenic syndrome treated with 3.4 diamino-pyridine is described. Despite symptomatic improvement and an improved electromyogram (EMG) on treatment, extreme sensitivity to neuromuscular block occurred with vecuronium. Antagonism of block was poor with an ant...
Gespeichert in:
| Veröffentlicht in: | British journal of anaesthesia : BJA 1990-03, Vol.64 (3), p.363-366 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 366 |
|---|---|
| container_issue | 3 |
| container_start_page | 363 |
| container_title | British journal of anaesthesia : BJA |
| container_volume | 64 |
| creator | TELFORD, R.J. HOLLWAY, T.E. |
| description | A case of anaesthesia in a patient with myasthenic syndrome treated with 3.4 diamino-pyridine is described. Despite symptomatic improvement and an improved electromyogram (EMG) on treatment, extreme sensitivity to neuromuscular block occurred with vecuronium. Antagonism of block was poor with an anti-cholinesterase, while oral 3.4 diaminopyridine improved neuromuscular transmission further. A combination of anticholinesterase with amino-pyridine may be the antagonistic combination of choice in this condition. |
| doi_str_mv | 10.1093/bja/64.3.363 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79728923</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S000709121738649X</els_id><sourcerecordid>79728923</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-84de144ded3410db2de19a53bb030b96a3d3fb93bdef7a4d50bd66d6867717183</originalsourceid><addsrcrecordid>eNptkEtLAzEQgIMoWh83r0IO4smtySZNNt5Cu9qA3Uq7Ij2FZJOFlb7ctIL_3pQWvXiZYWY-ZpgPgGuMuhgJ8mA_zAOjXdIljByBDqYcJ4xzfAw6CCGeIIHTM3AewgdCmKeidwpOseAoZaQDJuUwh6OZnMZcqD6czorBZDzKH6EsZL7rTpWEqoASvspS5UUJy0kuy3wA31U5hKRL4UDJkSrGr7OJGqgivwQntZkHf3XIF-DtKS_7w-Rl_Kz68iWpKEKbJKPOYxqDIxQjZ9NYCtMj1iKCrGCGOFJbQazzNTfU9ZB1jDmW7X7jOCMX4G6_d92uPrc-bPSiCZWfz83Sr7ZBc8HTTKQkgvd7sGpXIbS-1uu2WZj2W2Okdwp1VKgZ1URHhRG_Oezd2oV3f_DeWZzfHuYmVGZet2ZZNeEXY5ngROwwtsd8dPDV-FaHqvHLyrum9dVGu1Xz__0fifWDmA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79728923</pqid></control><display><type>article</type><title>THE MYASTHENIC SYNDROME: ANAESTHESIA IN A PATIENT TREATED WITH 3.4 DIAMINOPYRIDINE</title><source>MEDLINE</source><source>Oxford journals</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>TELFORD, R.J. ; HOLLWAY, T.E.</creator><creatorcontrib>TELFORD, R.J. ; HOLLWAY, T.E.</creatorcontrib><description>A case of anaesthesia in a patient with myasthenic syndrome treated with 3.4 diamino-pyridine is described. Despite symptomatic improvement and an improved electromyogram (EMG) on treatment, extreme sensitivity to neuromuscular block occurred with vecuronium. Antagonism of block was poor with an anti-cholinesterase, while oral 3.4 diaminopyridine improved neuromuscular transmission further. A combination of anticholinesterase with amino-pyridine may be the antagonistic combination of choice in this condition.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/64.3.363</identifier><identifier>PMID: 1970263</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>4-Aminopyridine - analogs & derivatives ; 4-Aminopyridine - pharmacology ; 4-Aminopyridine - therapeutic use ; Aged ; Amifampridine ; Anesthesia, General ; Anesthetics. Neuromuscular blocking agents ; Biological and medical sciences ; Glycopyrrolate - pharmacology ; Humans ; Lambert-Eaton Myasthenic Syndrome - drug therapy ; Male ; Medical sciences ; Myasthenic syndrome: 3.4 diaminopytidine ; Neostigmine - pharmacology ; Neuropharmacology ; Pharmacology. Drug treatments ; Potassium Channels - drug effects ; Vecuronium Bromide - antagonists & inhibitors ; Vecuronium Bromide - pharmacology</subject><ispartof>British journal of anaesthesia : BJA, 1990-03, Vol.64 (3), p.363-366</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-84de144ded3410db2de19a53bb030b96a3d3fb93bdef7a4d50bd66d6867717183</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6897393$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1970263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TELFORD, R.J.</creatorcontrib><creatorcontrib>HOLLWAY, T.E.</creatorcontrib><title>THE MYASTHENIC SYNDROME: ANAESTHESIA IN A PATIENT TREATED WITH 3.4 DIAMINOPYRIDINE</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><description>A case of anaesthesia in a patient with myasthenic syndrome treated with 3.4 diamino-pyridine is described. Despite symptomatic improvement and an improved electromyogram (EMG) on treatment, extreme sensitivity to neuromuscular block occurred with vecuronium. Antagonism of block was poor with an anti-cholinesterase, while oral 3.4 diaminopyridine improved neuromuscular transmission further. A combination of anticholinesterase with amino-pyridine may be the antagonistic combination of choice in this condition.</description><subject>4-Aminopyridine - analogs & derivatives</subject><subject>4-Aminopyridine - pharmacology</subject><subject>4-Aminopyridine - therapeutic use</subject><subject>Aged</subject><subject>Amifampridine</subject><subject>Anesthesia, General</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Biological and medical sciences</subject><subject>Glycopyrrolate - pharmacology</subject><subject>Humans</subject><subject>Lambert-Eaton Myasthenic Syndrome - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myasthenic syndrome: 3.4 diaminopytidine</subject><subject>Neostigmine - pharmacology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Potassium Channels - drug effects</subject><subject>Vecuronium Bromide - antagonists & inhibitors</subject><subject>Vecuronium Bromide - pharmacology</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtLAzEQgIMoWh83r0IO4smtySZNNt5Cu9qA3Uq7Ij2FZJOFlb7ctIL_3pQWvXiZYWY-ZpgPgGuMuhgJ8mA_zAOjXdIljByBDqYcJ4xzfAw6CCGeIIHTM3AewgdCmKeidwpOseAoZaQDJuUwh6OZnMZcqD6czorBZDzKH6EsZL7rTpWEqoASvspS5UUJy0kuy3wA31U5hKRL4UDJkSrGr7OJGqgivwQntZkHf3XIF-DtKS_7w-Rl_Kz68iWpKEKbJKPOYxqDIxQjZ9NYCtMj1iKCrGCGOFJbQazzNTfU9ZB1jDmW7X7jOCMX4G6_d92uPrc-bPSiCZWfz83Sr7ZBc8HTTKQkgvd7sGpXIbS-1uu2WZj2W2Okdwp1VKgZ1URHhRG_Oezd2oV3f_DeWZzfHuYmVGZet2ZZNeEXY5ngROwwtsd8dPDV-FaHqvHLyrum9dVGu1Xz__0fifWDmA</recordid><startdate>19900301</startdate><enddate>19900301</enddate><creator>TELFORD, R.J.</creator><creator>HOLLWAY, T.E.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900301</creationdate><title>THE MYASTHENIC SYNDROME: ANAESTHESIA IN A PATIENT TREATED WITH 3.4 DIAMINOPYRIDINE</title><author>TELFORD, R.J. ; HOLLWAY, T.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-84de144ded3410db2de19a53bb030b96a3d3fb93bdef7a4d50bd66d6867717183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>4-Aminopyridine - analogs & derivatives</topic><topic>4-Aminopyridine - pharmacology</topic><topic>4-Aminopyridine - therapeutic use</topic><topic>Aged</topic><topic>Amifampridine</topic><topic>Anesthesia, General</topic><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>Biological and medical sciences</topic><topic>Glycopyrrolate - pharmacology</topic><topic>Humans</topic><topic>Lambert-Eaton Myasthenic Syndrome - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myasthenic syndrome: 3.4 diaminopytidine</topic><topic>Neostigmine - pharmacology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Potassium Channels - drug effects</topic><topic>Vecuronium Bromide - antagonists & inhibitors</topic><topic>Vecuronium Bromide - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TELFORD, R.J.</creatorcontrib><creatorcontrib>HOLLWAY, T.E.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TELFORD, R.J.</au><au>HOLLWAY, T.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THE MYASTHENIC SYNDROME: ANAESTHESIA IN A PATIENT TREATED WITH 3.4 DIAMINOPYRIDINE</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>1990-03-01</date><risdate>1990</risdate><volume>64</volume><issue>3</issue><spage>363</spage><epage>366</epage><pages>363-366</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>A case of anaesthesia in a patient with myasthenic syndrome treated with 3.4 diamino-pyridine is described. Despite symptomatic improvement and an improved electromyogram (EMG) on treatment, extreme sensitivity to neuromuscular block occurred with vecuronium. Antagonism of block was poor with an anti-cholinesterase, while oral 3.4 diaminopyridine improved neuromuscular transmission further. A combination of anticholinesterase with amino-pyridine may be the antagonistic combination of choice in this condition.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>1970263</pmid><doi>10.1093/bja/64.3.363</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0912 |
| ispartof | British journal of anaesthesia : BJA, 1990-03, Vol.64 (3), p.363-366 |
| issn | 0007-0912 1471-6771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79728923 |
| source | MEDLINE; Oxford journals; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | 4-Aminopyridine - analogs & derivatives 4-Aminopyridine - pharmacology 4-Aminopyridine - therapeutic use Aged Amifampridine Anesthesia, General Anesthetics. Neuromuscular blocking agents Biological and medical sciences Glycopyrrolate - pharmacology Humans Lambert-Eaton Myasthenic Syndrome - drug therapy Male Medical sciences Myasthenic syndrome: 3.4 diaminopytidine Neostigmine - pharmacology Neuropharmacology Pharmacology. Drug treatments Potassium Channels - drug effects Vecuronium Bromide - antagonists & inhibitors Vecuronium Bromide - pharmacology |
| title | THE MYASTHENIC SYNDROME: ANAESTHESIA IN A PATIENT TREATED WITH 3.4 DIAMINOPYRIDINE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T08%3A51%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=THE%20MYASTHENIC%20SYNDROME:%20ANAESTHESIA%20IN%20A%20PATIENT%20TREATED%20WITH%203.4%20DIAMINOPYRIDINE&rft.jtitle=British%20journal%20of%20anaesthesia%20:%20BJA&rft.au=TELFORD,%20R.J.&rft.date=1990-03-01&rft.volume=64&rft.issue=3&rft.spage=363&rft.epage=366&rft.pages=363-366&rft.issn=0007-0912&rft.eissn=1471-6771&rft.coden=BJANAD&rft_id=info:doi/10.1093/bja/64.3.363&rft_dat=%3Cproquest_cross%3E79728923%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79728923&rft_id=info:pmid/1970263&rft_els_id=S000709121738649X&rfr_iscdi=true |