THE MYASTHENIC SYNDROME: ANAESTHESIA IN A PATIENT TREATED WITH 3.4 DIAMINOPYRIDINE

A case of anaesthesia in a patient with myasthenic syndrome treated with 3.4 diamino-pyridine is described. Despite symptomatic improvement and an improved electromyogram (EMG) on treatment, extreme sensitivity to neuromuscular block occurred with vecuronium. Antagonism of block was poor with an ant...

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Veröffentlicht in:	British journal of anaesthesia : BJA 1990-03, Vol.64 (3), p.363-366
Hauptverfasser:	TELFORD, R.J., HOLLWAY, T.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - analogs & derivatives 4-Aminopyridine - pharmacology 4-Aminopyridine - therapeutic use Aged Amifampridine Anesthesia, General Anesthetics. Neuromuscular blocking agents Biological and medical sciences Glycopyrrolate - pharmacology Humans Lambert-Eaton Myasthenic Syndrome - drug therapy Male Medical sciences Myasthenic syndrome: 3.4 diaminopytidine Neostigmine - pharmacology Neuropharmacology Pharmacology. Drug treatments Potassium Channels - drug effects Vecuronium Bromide - antagonists & inhibitors Vecuronium Bromide - pharmacology
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Zusammenfassung:	A case of anaesthesia in a patient with myasthenic syndrome treated with 3.4 diamino-pyridine is described. Despite symptomatic improvement and an improved electromyogram (EMG) on treatment, extreme sensitivity to neuromuscular block occurred with vecuronium. Antagonism of block was poor with an anti-cholinesterase, while oral 3.4 diaminopyridine improved neuromuscular transmission further. A combination of anticholinesterase with amino-pyridine may be the antagonistic combination of choice in this condition.
ISSN:	0007-0912 1471-6771
DOI:	10.1093/bja/64.3.363