Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant

We describe two patients with acute myeloid leukaemia (AML) associated with erythrophagocytosis and a pericentric inversion of chromosome 8, inv(8)(p11q13). The haematological features were indistinguishable from those of patients with the t(8;16) syndrome and its variants. Our observations emphasiz...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of haematology 1998-03, Vol.100 (3), p.561-563
Hauptverfasser:	Coulthard, Stephanie, Chase, Andrew, Orchard, Kim, Watmore, Ann, Vora, Ajay, Goldman, John M., Swirsky, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease acute myeloid leukaemia Adolescent Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Bone Marrow Transplantation Chromosome Breakage Chromosome Inversion Chromosomes, Human, Pair 16 - genetics Chromosomes, Human, Pair 8 - genetics cytogenetic variant Erythrocytes, Abnormal - physiology Female Hematologic and hematopoietic diseases Humans Infant Karyotyping Leukemia, Myeloid - blood Leukemia, Myeloid - drug therapy Leukemia, Myeloid - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis M4/M5 subtypes, erythrophagocytosis Medical sciences Phagocytosis - physiology t(8 16)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We describe two patients with acute myeloid leukaemia (AML) associated with erythrophagocytosis and a pericentric inversion of chromosome 8, inv(8)(p11q13). The haematological features were indistinguishable from those of patients with the t(8;16) syndrome and its variants. Our observations emphasize the importance of the breakpoint at 8p11 and the possible involvement of the MOZ gene in all these cases.
ISSN:	0007-1048 1365-2141
DOI:	10.1046/j.1365-2141.1998.00587.x