Lack of Polarized Type 1 or Type 2 Cytokine Profile in Asymptomatic HIV‐1‐Infected Patients During a Two‐Year Bimonthly Follow‐Up

The production of type 1 (interferon or IFN‐γ) and type 2 (interleukin or IL‐4 and IL‐10) cytokines by mitogen‐stimulated peripheral blood mononuclear cells (PBMCs) obtained from asymptomatic human immunodeficiency virus‐seropositive (HIV+) patients untreated with any antiviral, antibacterial or ant...

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Veröffentlicht in:Scandinavian journal of immunology 1998-02, Vol.47 (2), p.146-151
Hauptverfasser: Canaris, A D, Caruso, A, Licenziati, S, Cantalamessa, A, De Francesco, M A, Fallacara, F, Fiorentini, S, Dima, F, Martinelli, F, Manca, N, Balsari, A, Turano, A
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Sprache:eng
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Zusammenfassung:The production of type 1 (interferon or IFN‐γ) and type 2 (interleukin or IL‐4 and IL‐10) cytokines by mitogen‐stimulated peripheral blood mononuclear cells (PBMCs) obtained from asymptomatic human immunodeficiency virus‐seropositive (HIV+) patients untreated with any antiviral, antibacterial or antimycotic drugs, and from healthy individuals, was evaluated by quantitative ELISA. Patients who were HIV+ were characterized by the absence of abnormal cytokine production. The level of each cytokine differed among individuals in the same group with intersubject variations greater for HIV+ patients than for healthy individuals. The longitudinal evaluation of IFN‐γ, IL‐4 and IL‐10 production showed intrasubject variations which were particularly marked in HIV+ patients. Accordingly, HIV+ patients and, to a lesser extent, healthy individuals were characterized by a wide spectrum of possible profiles, which were confined to type 0 phenotype. In HIV+ patients no correlation was found between each cytokine level and the number of CD4+ T cells, not even in those with a falling CD4+ T‐cell count and clinical symptoms.
ISSN:0300-9475
1365-3083
DOI:10.1046/j.1365-3083.1998.00270.x