Distinct prevalence of antibodies to the E2 protein of GB virus C/hepatitis G virus in different parts of the world

Since the identification of the new human virus, GB virus C (GBV‐C)/hepatitis G virus (HGV), in 1995/1996, reverse transcription polymerase chain reaction remained the sole available diagnostic tool for GBV‐C/HGV infection. Recently, a serologic test based on the detection of antibodies to the putative envelope protein 2 (anti‐E2) has been introduced. We used this assay for a seroepidemiological survey including 3,314 healthy individuals from different parts of the world, 123 patients from Germany who were suspected to have an increased risk of acquiring GBV‐C/HGV infection, 128 multiple organ donors, and 90 GBV‐C/HGV RNA positive persons. In European countries, anti‐E2 seropositivity ranged from 10.9% (Germany) to 15.3% (Austria). In South Africa (20.3%) and Brazil (19.5%), even higher anti‐E2 prevalence rates were recorded. In Asian countries like Bhutan (3.9%), Malaysia (6.3%), and the Philippines (2.7%), anti‐E2 positivity was significantly lower. GBV‐C/HGV anti‐E2 prevalence in potential “risk groups,” i.e., patients on hemodialysis and renal transplant recipients, did not vary significantly from anti‐E2 seroprevalence in German blood donors. Anti‐E2 and GBV‐C/HGV RNA were found to be mutually exclusive, confirming the notion that anti‐E2 has to be considered as a marker of past infection. J. Med. Virol. 54:103–106, 1998. © 1998 Wiley‐Liss,Inc.