Distribution of olfactory receptor genes in the human genome

We demonstrate that members of the olfactory receptor (OR) gene family are distributed on all but a few human chromosomes. Through FISH analysis, we show that OR sequences reside at more than 25 locations in the human genome. Their distribution is biased for terminal bands. Flow-sorted chromosomes w...

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Veröffentlicht in:	Nature genetics 1998-03, Vol.18 (3), p.243-250
Hauptverfasser:	Rouquier, Sylvie, Trask, Barbara J, Brand-Arpon, Véronique, Engh, Ger van den, Taviaux, Sylvie, Demaille, Jacques, Giorgi, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Amino Acid Sequence Animal Genetics and Genomics Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Chromosome Mapping Chromosomes, Human Chromosomes, Human, Pair 17 Classical genetics, quantitative genetics, hybrids Cloning, Molecular Conserved Sequence DNA Primers Fundamental and applied biological sciences. Psychology Gene Function Genetic Techniques Genetics of eukaryotes. Biological and molecular evolution Human Human Genetics Humans In Situ Hybridization, Fluorescence Introns Molecular Sequence Data Multigene Family Receptors, Odorant - genetics Sequence Analysis Sequence Homology, Amino Acid
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Zusammenfassung:	We demonstrate that members of the olfactory receptor (OR) gene family are distributed on all but a few human chromosomes. Through FISH analysis, we show that OR sequences reside at more than 25 locations in the human genome. Their distribution is biased for terminal bands. Flow-sorted chromosomes were used to isolate 87 OR sequences derived from 16 chromosomes. Their sequence-relationships are indicative of the inter- and intrachromosomal duplications responsible for OR family expansion. The human genome has accumulated a striking number of dysfunctional copies: 72% of the sequences are pseudogenes. ORF-containing sequences predominate on chromosomes 7,16 and 17.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng0398-243