E-series prostaglandins and arginine vasopressin in the modulation of male sexual behavior

Studies carried out recently in the author's laboratory have suggested that fever accompanies copulation in the male rat. Given the action of prostaglandin-E (PGE) in the genesis of fever and given the integrative role of the medial preoptic area (MPOA) in the expression of both fever and male sexual behavior, two hypotheses were advanced concerning male copulation. The first concerns PGE in facilitating transmission in MPOA pathways mediating mounting, intromission and ejaculation. The second concerns arginine vasopressin, a presumed “natural antagonist” of PGE, in inhibiting such transmission and eventually making the male refractory to the receptive female. Several experiments were suggested for testing each hypothesis.