Neuron—glia interactions: effect of serotonin on the astroglial expression of GFAP and of its encoding message

The trophic effect of serotonin on the glial fibrillary acidic protein (GFAP) expression was investigated in rat brainstem astrocytes in primary culture. GFAP immunolabelling decreased and gliofilaments appeared localized in the cytoplasm periphery. GFAP protein level decreased in parallel with a de...

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Veröffentlicht in:	Brain research. Developmental brain research 1990-02, Vol.51 (2), p.295-298
Hauptverfasser:	Le Prince, G., Copin, M.-C., Hardin, H., Belin, M.-F., Bouilloux, J.-P., Tardy, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocyte primary culture Brain Stem - cytology Brain Stem - drug effects Brain Stem - metabolism Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - genetics Glial Fibrillary Acidic Protein - metabolism Neuroglia - cytology Neuroglia - drug effects Neuroglia - metabolism Rat Rats RNA, Messenger - metabolism Serotonin Serotonin - pharmacology
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Zusammenfassung:	The trophic effect of serotonin on the glial fibrillary acidic protein (GFAP) expression was investigated in rat brainstem astrocytes in primary culture. GFAP immunolabelling decreased and gliofilaments appeared localized in the cytoplasm periphery. GFAP protein level decreased in parallel with a decrease in its encoding message. Serotonin may act as an inhibitor of GFAP expression either on the transcription or on the stability of the GFAP-mRNA.
ISSN:	0165-3806
DOI:	10.1016/0165-3806(90)90290-F