Early viral complications following CD34‐selected autologous peripheral blood stem cell transplantation for non‐Hodgkin's lymphoma

A patient with non‐Hodgkin's lymphoma who received a CD34‐selected autologous peripheral blood stem cell transplant (PBSCT) developed cytomegalovirus retinitis, adenovirus‐associated haemorrhagic cystitis (HC) and fatal herpes simplex virus pneumonia. Depletion of mature T cells from the graft...

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Veröffentlicht in:	British journal of haematology 1998-02, Vol.100 (2), p.348-350
Hauptverfasser:	Miyamoto, Toshihiro, Gondo, Hisashi, Miyoshi, Yasushi, Shigematsu, Hirokazu, Minematsu, Toshio, Takenaka, Katsuto, Tanimoto, Kazuki, Horiuchi, Takahiko, Asano, Yoshinobu, Inaba, Shoichi, Minamishima, Yoichi, Niho, Yoshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Infections - complications Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens, CD34 Biological and medical sciences Bone marrow, stem cells transplantation. Graft versus host reaction CD34+ cells Cytomegalovirus Retinitis - complications Fatal Outcome Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Herpes Simplex - complications Humans immunodeficiency Immunosuppression - adverse effects Lymphoma, Large B-Cell, Diffuse - complications Lymphoma, Large B-Cell, Diffuse - therapy Lymphoma, T-Cell - complications Lymphoma, T-Cell - therapy Male Medical sciences Middle Aged Opportunistic Infections - complications Pneumonia, Viral - complications stem cell transplantation Transfusions. Complications. Transfusion reactions. Cell and gene therapy viral infection Virus Diseases - complications
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Beschreibung
Zusammenfassung:	A patient with non‐Hodgkin's lymphoma who received a CD34‐selected autologous peripheral blood stem cell transplant (PBSCT) developed cytomegalovirus retinitis, adenovirus‐associated haemorrhagic cystitis (HC) and fatal herpes simplex virus pneumonia. Depletion of mature T cells from the graft and a persistent decrease in CD4+ lymphocytes following PBSCT may have predisposed this patient to such viral infections. Infusion of cryopreserved autologous PBSC (containing mature T cells) was effective for adenovirus‐associated HC. Immunosuppression and resultant viral infections may affect patients receiving CD34‐selected autologous transplantation.
ISSN:	0007-1048 1365-2141
DOI:	10.1046/j.1365-2141.1998.00572.x