Lack of association between human leukocyte antigens and the anti-Hu syndrome in patients with small-cell lung cancer

We compared the human leukocyte antigen alleles found in a group of 17 patients with small-cell lung cancer (SCLC), paraneoplastic neurologic syndromes (PNS), and high titers of anti-Hu autoantibodies with those in 30 patients with SCLC but no PNS and no anti-Hu antibodies (control group). There was...

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Veröffentlicht in:	Neurology 1998-02, Vol.50 (2), p.565-566
Hauptverfasser:	UCHUYA, M, FLEURY, A, GRAUS, F, COSTAGLIOLA, D, LIBLAU, R, MERLE-BERAL, H, THEODOROU, I, DELATTRE, J.-Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Autoantibodies - blood Autoimmune Diseases - immunology Biological and medical sciences Carcinoma, Small Cell - genetics Carcinoma, Small Cell - immunology Cytotoxicity, Immunologic Histocompatibility Testing HLA-A Antigens - genetics HLA-B Antigens - genetics HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Lung Neoplasms - genetics Lung Neoplasms - immunology Medical sciences Nervous System Diseases - genetics Nervous System Diseases - immunology Paraneoplastic Syndromes - immunology Pneumology Tumors of the respiratory system and mediastinum
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Zusammenfassung:	We compared the human leukocyte antigen alleles found in a group of 17 patients with small-cell lung cancer (SCLC), paraneoplastic neurologic syndromes (PNS), and high titers of anti-Hu autoantibodies with those in 30 patients with SCLC but no PNS and no anti-Hu antibodies (control group). There was no difference between the two groups, suggesting that specific haplotypes are not required for the development of the "anti-Hu syndrome."
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.50.2.565