LDL Oxidation and Extent of Coronary Atherosclerosis

Accumulated evidence indicates that oxidative modification of LDL plays an important role in the atherogenic process. Therefore, we investigated the relation between coronary atherosclerosis and susceptibility of LDL to oxidation in a case-control study in men between 45 and 80 years of age. Case su...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 1998-02, Vol.18 (2), p.193-199
Hauptverfasser:	van de Vijver, Lucy P.L, Kardinaal, Alwine F.M, Kruijssen, Dick A.C.M, Grobbee, Diederick E, van Poppel, Geert, Princen, Hans M.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Coronary Angiography Coronary Artery Disease - blood Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - etiology Female Humans Lipoproteins - metabolism Male Medical sciences Middle Aged Odds Ratio Oxidation-Reduction Predictive Value of Tests Risk Factors
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Beschreibung
Zusammenfassung:	Accumulated evidence indicates that oxidative modification of LDL plays an important role in the atherogenic process. Therefore, we investigated the relation between coronary atherosclerosis and susceptibility of LDL to oxidation in a case-control study in men between 45 and 80 years of age. Case subjects and hospital control subjects were selected from subjects undergoing a first coronary angiography. Subjects with severe coronary stenosis (>or= to 85% stenosis in one and >or= to 50% stenosis in a second major coronary vessel) were classified as case subjects (n = 91). Hospital control subjects with no or minor stenosis (
ISSN:	1079-5642 1524-4636
DOI:	10.1161/01.ATV.18.2.193