Ion channels and exchangers that mediate ischemic neuronal injury

Ion channels and exchangers that mediate ischemic neuronal injury

Preventing the loss of ion homeostasis or promoting its recovery are two primary targets of neuroprotective strategies. The contribution of excitatory neurotransmitter receptor linked ion channels is now well established. Sodium and calcium may also enter neurons and glia through voltage sensitive c...

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Veröffentlicht in:Current opinion in neurology 1998-02, Vol.11 (1), p.39-43
1. Verfasser: Vornov, J J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antiporters - physiology
Cation Exchange Resins - metabolism
Humans
Ion Channels - physiology
Ischemia - etiology
Ischemia - metabolism
Ischemia - physiopathology
Peripheral Nervous System Diseases - etiology
Peripheral Nervous System Diseases - metabolism
Peripheral Nervous System Diseases - physiopathology
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Zusammenfassung:Preventing the loss of ion homeostasis or promoting its recovery are two primary targets of neuroprotective strategies. The contribution of excitatory neurotransmitter receptor linked ion channels is now well established. Sodium and calcium may also enter neurons and glia through voltage sensitive channels and exchangers, contributing directly and indirectly to injury.
ISSN:1350-7540
DOI:10.1097/00019052-199802000-00007