Platelet Activating Factor Antagonist Activity of Ginsenosides

Ginseng saponins and their degradation products have been screened for antagonist activity towards [3H]PAF (platelet activating factor) in washed rabbit platelet receptor binding studies. 20(S)- and Δ20-ginsenosides Rg3, protopanaxadiol-type saponins, were found to be relatively potent PAF antagonis...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1998/01/15, Vol.21(1), pp.79-80
Hauptverfasser:	JUNG, Keun Young, KIM, Dong Seon, OH, Sei Ryang, LEE, Im Seon, LEE, Jung Joon, PARK, Jong Dae, KIM, Shin Il, LEE, Hyeong-Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	20(S)-ginsenoside Rg3 Animals Biological and medical sciences Blood Platelets - drug effects Blood Platelets - metabolism Buffers General pharmacology Ginsenosides In Vitro Techniques Indicators and Reagents Medical sciences PAF antagonistic activity Panax - chemistry Panax ginseng Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal Platelet Activating Factor - antagonists & inhibitors Platelet Membrane Glycoproteins - metabolism Rabbits Receptors, Cell Surface Receptors, G-Protein-Coupled Saponins - pharmacology Δ20-ginsenoside Rg3
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Beschreibung
Zusammenfassung:	Ginseng saponins and their degradation products have been screened for antagonist activity towards [3H]PAF (platelet activating factor) in washed rabbit platelet receptor binding studies. 20(S)- and Δ20-ginsenosides Rg3, protopanaxadiol-type saponins, were found to be relatively potent PAF antagonists (IC50=4.9×10-5M and 9.2×10-5M, respectively).
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.21.79